Dr Simon Rawlinson, BSc (Hons), PhD
Lecturer Oral physiology
email: s.c.f.rawlinson@qmul.ac.uk
Phone: +44 20 7882 7139
Fax: +44 20 7377 7064
Institute of Dentistry
Barts and The London
School of Medicine and Dentistry
4 Newark Street
London
E1 2AT
United Kingdom
North East London Polytechnic 1985 BSc (Hons) Applied Biology.
The Royal Veterinary College 1999 PhD Veterinary Anatomy. ‘Early loading-related responses of resident cells in mammalian bone organ explants’.
Research Technician, Bone Unit, The Royal Veterinary College 1986-2000
Research Associate, Bone Unit, The Royal Veterinary College 2000-2003
Research Associate, Queen Mary University of London, Barts & The London School of Medicine and Dentistry, Institute of Dentistry 2003-2009
Lecturer, Queen Mary University of London, Barts & The London School of Medicine and Dentistry, Institute of Dentistry 2009-
Publications:
El-Haj AJ, Minter SL, Rawlinson SCF, Suswillo R, Lanyon LE. Cellular responses to mechanical loading in vitro. J Bone Miner Res 1990; 5: 923-932.
Rawlinson SCF, El-Haj AJ, Minter SL, Tavares IA, Bennett A, Lanyon LE. Loading-related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: a role for prostacyclin in adaptive bone remodeling? J Bone Miner Res 1991; 6: 1345-1351.
Rawlinson SCF, Mohan S, Baylink DJ, Lanyon LE. Exogenous prostacyclin, but not prostaglandin E2, produces similar responses in both G6PD activity and RNA production as mechanical loading, and increases IGF-II release, in adult cancellous bone in culture. Calcif Tissue Int 1993; 53: 324-329.
Pitsillides AA, Rawlinson SCF, Suswillo RF, Bourrin S, Zaman G, Lanyon LE. Mechanical strain-induced NO production by bone cells: a possible role in adaptive bone (re)modeling? FASEB J 1995; 9: 1614-1622.
Rawlinson SCF, Mosley JR, Suswillo RF, Pitsillides AA, Lanyon LE. Calvarial and limb bone cells in organ and monolayer culture do not show the same early responses to dynamic mechanical strain. J. Bone Miner. Res. 1995; 10: 1225-1232.
Rawlinson SCF, Pitsillides AA, Lanyon LE. Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain. Bone 1996; 19: 609-614.
Cheng MZ, Zaman G, Rawlinson SCF, Suswillo RF, Lanyon LE. Mechanical loading and sex hormone interactions in organ cultures of rat ulna. J Bone Miner Res 1996; 11: 502-511.
Cheng MZ, Zaman G, Rawlinson SCF, Pitsillides AA, Suswillo RF, Lanyon LE. Enhancement by sex hormones of the osteoregulatory effects of mechanical loading and prostaglandins in explants of rat ulnae. J Bone Miner Res 1997; 12: 1424-1430.
Rawlinson SCF, Zaman G, Mosley JR, Pitsillides AA, Lanyon LE. Heme oxygenase isozymes in bone: induction of HO-1 mRNA following physiological levels of mechanical loading in vivo. Bone 1998; 23: 433-436.
Cheng M, Zaman G, Rawlinson SCF, Mohan S, Baylink DJ, Lanyon LE. Mechanical strain stimulates ROS cell proliferation through IGF-II and estrogen through IGF-I. J Bone Miner Res 1999; 14: 1742-1750.
Zaman G, Pitsillides AA, Rawlinson SCF, Suswillo RF, Mosley JR, Cheng MZ, Platts LA, Hukkanen M, Polak JM, Lanyon LE. Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes. J Bone Miner Res 1999; 14: 1123-1131.
Pitsillides AA, Rawlinson SCF, Mosley JR, Lanyon LE. Bone's early responses to mechanical loading differ in distinct genetic strains of chick: selection for enhanced growth reduces skeletal adaptability. J Bone Miner Res 1999; 14: 980-987.
Rawlinson SCF, Wheeler-Jones CP, Lanyon LE. Arachidonic acid for loading induced prostacyclin and prostaglandin E(2) release from osteoblasts and osteocytes is derived from the activities of different forms of phospholipase A(2). Bone 2000; 27: 241-247.
Jessop HL, Rawlinson SCF, Pitsillides AA, Lanyon LE. Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways. Bone 2002; 31: 186-194.
Cheng MZ, Rawlinson SCF, Pitsillides AA, Zaman G, Mohan S, Baylink DJ, Lanyon LE. Human osteoblasts' proliferative responses to strain and 17beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I. J Bone Miner Res 2002; 17: 593-602.
Jessop HL, Suswillo RF, Rawlinson SCF, Zaman G, Lee K, Das-Gupta V, Pitsillides AA, Lanyon LE. Osteoblast-like cells from estrogen receptor alpha knockout mice have deficient responses to mechanical strain. J Bone Miner Res 2004; 19: 938-946.
Chambler A, Rawlinson SCF, Emery R, Pitsillides A. Quantitative cytochemical evidence for local increases in bone turnover at the acromial enthesis of the human coracoacromial ligament. J Rheumatol 2004; 31: 2216-2225.
de Souza RL, Matsuura M, Eckstein F, Rawlinson SCF, Lanyon LE, Pitsillides AA. Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: A new model to study cortical and cancellous compartments in a single loaded element. Bone 2005; 37: 810-818.
Simon DW, Clarkin CE, Das-Gupta V, Rawlinson SCF, Emery RJ, Pitsillides AA. Identifying the cellular basis for reimplantation failure in repair of the rotator cuff. J Bone Joint Surg Br 2008; 90: 680-684.
Rawlinson SCF, Boyde A, Davis GR, Howell PG, Hughes FJ, Kingsmill VJ. Ovariectomy vs. hypofunction: their effects on rat mandibular bone. J Dent Res 2009; 88: 615-620.
Rawlinson SCF, McKay IJ, Ghuman M, Wellmann C, Ryan P, Prajaneh S, Zaman G, Hughes FJ, Kingsmill VJ. Adult Rat Bones Maintain Distinct Regionalized Expression of Markers Associated with Their Development. PLoS ONE 2009; 4: e8358.
Kingsmill VJ, Boyde A, Davis GR, Howell PG, Rawlinson SCF. Changes in Bone Mineral and Matrix in Response to a Soft Diet. J Dent Res 2010; 89: 510-514.
Book Chapter
Pitsillides AA, Das-Gupta V, Simon D, Rawlinson SCF. Methods for analyzing bone cell responses to mechanical loading using in vitro monolayer and organ culture models. In: Bone Research Protocols (Methods Mol Med) ed, Helfrich MH and Ralston SH, 2003; 80: 399-422
Research interests:
Mechanical responsiveness of bone tissues
Mechanisms that regulate the ‘mechanostat’
Regional variations in skeletal tissue based on embryonic derivation and local loading environment
Osteogenic biomaterials