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Institute of Dentistry

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Professor Mike Curtis, BSc, PhD

Mike

Dean of Dentistry

Email: m.a.curtis@qmul.ac.uk
Telephone: +44 20 7882 2300
Room Number: Institute of Dentistry

Profile

Following his PhD in the Institute of Basic Medical Sciences London University, he performed his post-doctoral research on microbial anaerobic metabolism in oral bacteria as a visiting Fogarty Fellow at the National Institutes of Health (1980-1985) in Bethesda MD USA. He returned to the UK to a tenured position with the MRC based at the London Hospital Medical College and was appointed Professor of Microbiology with Barts and The London School of Medicine and Dentistry in 2000. From 2002-4, he was Dean for Research of the School and in 2003 was appointed Director of the Blizard Institute. He was made Honorary FDSRCS (Eng) in 2008 and Fellow of the Academy of Medical Sciences in 2009.

Research

Research Interests:

Current research is focused in two main areas. First, the role of the oral microbiome in the maintenance of oral health and the development of disease and secondly analysis of the key microbial virulence determinants of oral bacteria.

Study of the oral microbiome involves the use of a mouse model to understand the factors which govern the perturbation of a health associated microbial population structure into a microbiome associated with inflammatory disease of the periodontal tissues and the influence of these symbiotic and dysbiotic microbiota on the immune and inflammatory systems of the host. Virulence studies are directed towards understanding the role of surface and extracellular virulence factors of oral bacteria, in particular Porphyromonas gingivalis - one of the key pathogens in human periodontal disease. These studies involve analysis of the biochemistry and genetics of biosynthesis of lipo-polysaccharides produced by this organism as well as extracellular proteolytic enzymes.

Selected Publications:

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