Professor Mike Curtis, BSc, PhD
Dean of Dentistry
Email: firstname.lastname@example.orgTelephone: +44 20 7882 2300Room Number: Institute of Dentistry
Following his PhD in the Institute of Basic Medical Sciences London University, he performed his post-doctoral research on microbial anaerobic metabolism in oral bacteria as a visiting Fogarty Fellow at the National Institutes of Health (1980-1985) in Bethesda MD USA. He returned to the UK to a tenured position with the MRC based at the London Hospital Medical College and was appointed Professor of Microbiology with Barts and The London School of Medicine and Dentistry in 2000. From 2002-4, he was Dean for Research of the School and in 2003 was appointed Director of the Blizard Institute. He was made Honorary FDSRCS (Eng) in 2008 and Fellow of the Academy of Medical Sciences in 2009.
Current research is focused in two main areas. First, the role of the oral microbiome in the maintenance of oral health and the development of disease and secondly analysis of the key microbial virulence determinants of oral bacteria.
Study of the oral microbiome involves the use of a mouse model to understand the factors which govern the perturbation of a health associated microbial population structure into a microbiome associated with inflammatory disease of the periodontal tissues and the influence of these symbiotic and dysbiotic microbiota on the immune and inflammatory systems of the host. Virulence studies are directed towards understanding the role of surface and extracellular virulence factors of oral bacteria, in particular Porphyromonas gingivalis - one of the key pathogens in human periodontal disease. These studies involve analysis of the biochemistry and genetics of biosynthesis of lipo-polysaccharides produced by this organism as well as extracellular proteolytic enzymes.
Rangarajan M, Aduse-Opoku J, Paramonov N, Hashim A, Bostanci N, Fraser OP, Tarelli E, Curtis MA. (2008) Identification of a second lipopolysaccharide in Porphyromonas gingivalis W50. J Bacteriol. 190:2920-32.
Paramonov NA, Aduse-Opoku J, Hashim A, Rangarajan M and MA Curtis (2009) Structural Analysis of the Core-Region of O-Lipopolysaccharide of Porphyromonas gingivalis from mutants defective in O-antigen ligase and O-antigen polymerase. J Bacteriol. 191:5272-82
Paramonov NA, Aduse-Opoku J, Hashim A, Rangarajan M, Curtis MA (2009) Structural analysis of the core region of O-lipopolysaccharide of Porphyromonas gingivalis from mutants defective in O-antigen ligase and O-antigen polymerase. J Bacteriol. 191:5272-82.
M.F. Haurat, Aduse-Opoku J, Rangarajan M, Dorobantu I, Gray MR, Curtis MA and Feldman M (2011) Selective sorting of cargo proteins into bacterial membrane vesicles. J Biol Chem 286:1269-1276.
Curtis MA, Zenobia C, Darveau RP (2011) The relationship of the oral microbiota to periodontal health and disease. Cell Host Microbe 10:302-306.
Hajishengallis G, Liang S, Payne MA, Hashim A, Jotwani R, Eskan MA, McIntosh ML, Alsam A, Kirkwood KL, Lambris JD, Darveau RP, Curtis MA (2011) Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement Cell Host & Microbe 10:1-10.
Eskan MA, Jotwani R, Abe T, Chmelar J, Lim JH, Liang S, Ciero PA, Krauss JL, Li F, Rauner M, Hofbauer LC, Choi EY, Chung KJ, Hashim A, Curtis MA, Chavakis T, Hajishengallis G. (2012) The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss. Nat Immunol 13(5):465-473.