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Institute of Dentistry

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Professor David Williams, BDS (Hons), MSc, PhD, FRCPath, FDS RCS (Engl)

Professor of Global Oral Health, Lead for International Partnerships

email: d.m.williams@qmul.ac.uk
Tel: +44 20 7882 8632

Profile

David Williams

Read Prof William's recent interview by the World Health Organisation "Dentistry at a tipping point".

Present Position

Research Professor of Global Oral Health, Bart's and the London School of Medicine and Dentistry, Queen Mary, University of London

Chair and Convener, Global Oral Health Inequalities Research Agenda (GOHIRA) Initiative, International Association for Dental

Non Executive Director, South Central Ambulance Services NHS Trust

Recent Previous Appointments

2010-2011 Vice Provost, University of Southampton

2004-2010 Dean, Faculty of Medicine, Health and Life Sciences, University of Southampton

2009-2010 President International Association for Dental Research

Oral diseases constitute a major health burden on a global scale, and major inequalities exist both within and between countries in terms of severity and prevalence.  They remain a major public health issue for high-income countries and constitute a severe and growing problem in low-to-middle income countries.  The issue of global health has come to international prominence in recent years, with the realisation that radically different approaches to their management are going to be needed.  It is recognised that the non-communicable diseases associated with lifestyle have become the major challenge for us, as infectious disease has been largely brought under control for now in the more affluent countries.  It also coming to be recognised that oral health needs to be accorded the same consideration as cancer, heart disease, obesity and mental health.

Teaching

Research

Research interests:

Global oral Health Inequalities

Current major research interest is in global inequalities in oral health.  In this context the appointment as Convener of the International Association for Dental Research Initiative on Global Oral Health Inequalities is particularly salient.

Oral diseases constitute a major health burden on a global scale, and major inequalities exist both within and between countries in terms of severity and prevalence.  They remain a major public health issue for high-income countries and constitute a severe and growing problem in low-to-middle income countries.  The issue of global health has come to international prominence in recent years, with the realisation that radically different approaches to their management are going to be needed.  It is recognised that the non-communicable diseases associated with lifestyle have become the major challenge for us, as infectious disease has been largely brought under control for now in the more affluent countries.  It also coming to be recognised that oral health needs to be accorded the same consideration as cancer, heart disease, obesity and mental health.

Selected publications:

Key Publications

WILLIAMS DM. 2011.  Guest Editor: Global Oral Health Inequalities: the Research Agenda.  Adv Dent Res 23(2): 197-267

WILLIAMS DM. 2011. Global Oral Health Inequalities: the research agenda. Adv Dent Res 23 (2): 198-200

WILLIAMS DM. 2011. Guest Editorial: Global Oral Health Inequalities: the research agenda. J Dent Res 90: 549-551

WILLIAMS DM. 2011. Reducing Inequalities in Oral Disease. Brit Dent J 210: 393

URDEA MS, NEUWALD, GREENBERG, GLICK M, GALLOWAY J, WILLIAMS DM, WONG DTW. 2011.  Saliva, Diagnostics and Dentistry. Adv Dent Res 23(4) : 353-59

Structure and function of oral mucosa

LESCH CA, SQUIER CA, CRUCHLEY AT, WILLIAMS DM, SPEIGHT PM.  1989

CRUCHLEY AT, WILLIAMS DM, FARTHING PM, SPEIGHT PM, LESCH CA, SQUIER CA. 1994

Langerhans cell density in normal human oral mucosa and skin:  relationship to age, smoking and alcohol consumption.  J Oral Pathol Med 1994; 23: 55-59.

CRUCHLEY AT, WILLIAMS DM, FARTHING PM, SPEIGHT PM, LESCH CA, SQUIER CA. 1994

Langerhans cell density in normal human oral mucosa and skin:  relationship to age, smoking and alcohol consumption.  J Oral Pathol Med 1994; 23: 55-59.

Mucosal disease with special reference to HIV infection
WILLIAMS DM, LEIGH IM, GREENSPAN D and GREENSPAN JS.  1991

Altered patterns of keratin expression in oral hairy leukoplakia:  prognostic implications.  J Oral Pathol Med 20: 167-71.

KING GN, HEALY CM, GLOVER MT, KWAN JTC, WILLIAMS DM, LEIGH IM, WORTHINGTON HV, THORNHILL MH. 1995  Increased prevalence of dysplastic and malignant lip lesions in renal transplant recipients.  New Engl J Med 332: 1052-7.

Mucosal defence and interactions with pathogens

SCRAGG MA, TURTON LR and WILLIAMS DM.  1991.  Differential morphological changes in human polymorphonuclear leucocytes induced by culture products of Porphyromonas (Bacteroides) gingivalis W50 and its colonial variants with reduced virulence.  Arch Oral Biol 36: 709-714.

SCRAGG MA, TURTON LR, NEWMAN HN, WILLIAMS DM.  1995.  Effects of Porphyromonas gingivalis culture products on the morphology of peripheral blood polymorphonuclear leucocytes from periodontitis patients and healthy subjects.  J Clin Periodontol 22: 585-590.

SCRAGG MA, CANNON SJ, WILLIAMS DM.  1996.  The secreted products of Porphyromonas gingivalis alter human gingival fibroblast morphology by selective damage to integrin-substrate interactions.  Microb Ecol in Health & Dis.  9: 167-179.

SCRAGG MA, CANNON SJ, RANGARAJAN M, WILLIAMS DM & CURTIS MA.  1999.  Targeted disruption of fibronectin/integrin interactions in human gingival fibroblasts by the RI protease of Porphyromonas gingivalis W50.  Infect Immun 67:1837-1843.

SCRAGG MA, ALSAM A, RANGARANJAN M, SLANEY JM, SHEPHERD P, WILLIAMS DM & CURTIS MA 2002.  Nuclear targeting of Porphyromonas gingivalis W50 protease in epithelial cells.  Infect Immun 70: 5740-5750

DOMMISCH H, CHUNG WO, ROHANI MG, WILLIAMS DM, RANGARAJAN M, CURTIS MA, DALE BA. 2007. Protease-activated receptor-2 mediates hBD-2 and CCL20 Mrna expression in response to proteases secreted by Porphyromonas gingivalis  Infect Immun 75: 4326-33

PhD Supervision

Public engagement

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