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Institute of Dentistry

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Professor Alan Boyde, PhD, BDS, LDSRCS, MDhc, FRMS, FAS

Professor of Mineralised Tissue Biology

email: a.boyde@qmul.ac.uk
Tel: +44 20 7882 5838

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Alan Boyde

• Thomas Henry Huxley award, Zoological Society of London, 1964.
• Sir Frank Collyer Award, Royal Society of Medicine, 1965.
• Grand Prix d'ORCA (European Caries Research Organisation), 1966.
• Fellow, Royal Microscopical Society, 1974.
• Isaac Schour Memorial Award, International Association for Dental Research, 1980.
• Biological Council Medal awarded via The Royal Microscopical Society, 1986.
• (First) Anatomical Society Review Lecturer, 1986.
• Medal of the Brazilian Odontological Association, 1987.
• Honorary Founder Member of Association for Dental Implantology, 1987.
• Sir John Tomes Medal, Royal College of Surgeons of England, 1988.
• Basic Research in Biological Mineralisation Award, International Association for Dental Research, 1989.
• Robert Hooke Award, International Society for Analytical Cytology, 1991.
• Medal of the Fondation Singer-Polignac, Paris, 1996.
• Doctor Honoris Causae, Medicine, Charles University of Prague, 1996.
• Wellcome Trust Biomedical Imaging Awards, 1998 & 2002.
• President, Anatomical Society, 2002-2004.
• Honorary Member, Bone Research Society, 2002.
• Novartis / Daily Telegraph Visions of Science Award, 2002.
• Professor Emeritus, Cell and Developmental Biology, UCL, 2003.
• Abbe Lecturer, Royal Microscopical Society, 2003.
• Evelyn Sprawson Lecturer, London Hospital Dental Club, 2008.
• Bone Research Society, (First) Charles Dent Memorial Lecturer, 2009.
• Honorary Visiting Professor of Skeletal Biology, University of Suffolk, 2010.
• Slack Medal, Bart's & The London School of Medicine and Dentistry, 2011.
• Fellow Anatomical Society, 2012: Honorary Fellow, 2013.
• European Calcified Tissue Society, Excellence in Research Lecturer, 2013.
• Honorary Professor, Medicine (Mol. Endocrinol.), Imperial College London, 2015.
• Honorary Professor, Experimental Biophotonics, CEITEC, Brno, CZ, 2016.
• Bone Research Society, Invited Lecturer, Liverpool, 2016.
• Bloomsbury Centre for Skeletal Research, Lecturer, Inaugural meeting, 2016.

Teaching

Research

Research interests:

Dental and skeletal hard tissue development, structure, function, disease and treatment.

Skeletal tissue responses to hormonal and drug challenges, impact exercise, aging, osteomalacia, osteoporosis, osteoarthritis, traumatic osteochondrosis, fatigue fracture, dental and skeletal implants, tumour metastases.

Skeletal changes in genetically modified mice.

Selected publications:

  • null (2009) Lamellar Bone is an Incremental Tissue Reconciling Enamel Rhythms, Body Size, and Organismal Life History. CALCIFIED TISSUE INT. vol.84 (5) pp.388-404

View all publications

Key Publications

Detection of early osteoarthritis in the centrodistal joints of Icelandic horses: Evaluation of radiography and low-field magnetic resonance imaging. Ley CJ, Björnsdóttir S, Ekman S, Boyde A, Hansson K.Equine Vet J. 2014 Oct 7. doi: 10.1111/evj.12370.

Thyroid hormone receptor α mutation causes a severe and thyroxine-resistant skeletal dysplasia in female mice. Bassett JH, Boyde A, Zikmund T, Evans H, Croucher PI, Zhu X, Park JW, Cheng SY, Williams GR. Endocrinology. 2014 Sep;155(9):3699-712. doi: 10.1210/en.2013-2156.

Constitutive Expression of Gsα(R201C) in Mice Produces a Heritable, Direct Replica of Human Fibrous Dysplasia Bone Pathology and Demonstrates Its Natural History. Saggio I, Remoli C, Spica E, Cersosimo S, Sacchetti B, Robey PG, Holmbeck K, Cumano A, Boyde A, Bianco P, Riminucci M. J Bone Miner Res. 2014 Nov;29(11):2357-68. doi: 10.1002/jbmr.2267.

Boyde A (1989) Enamel. In: Handbook of Microscopic Anatomy Vol V/6, pp309-473: A Oksche and L Vollrath (Eds) Springer Verlag, Berlin.

Jones SJ, Boyde A (1984) Ultrastructure of dentin and dentinogenesis.  In: Dentin and Dentinogenesis I, pp81-134: Linde A (Ed), CRC Press, Boca Raton, Florida.

Boyde A (1972) Scanning electron microscopic studies of bone. In: The Biochemistry and Physiology of Bone, 2nd edn, Vol.1, pp259-310 Bourne GH (Ed) Academic Press, New York.

Boyde A (1974) Three-dimensional aspects of SEM images. chapter 11 pp277-336, In: Oliver C Wells (Ed), Scanning electron microscopy, McGraw-Hill book company, New York.

Boyde A, Jones SJ (1983) Scanning electron microscopy of cartilage. In: Cartilage I: 105-148, Hall BK (Ed), Academic Press, New York.

Boyde A (1990) Confocal Optical Microscopy. In: Modern Microscopies: Techniques and Applications, pp185-204: PJ Duke and AG Michette (Eds) Plenum, New York.

Boyde A, Travers R, Glorieux FH, Jones SJ (1999) The mineralisation density of iliac crest bone from children with osteogenesis imperfecta. Calcified Tissue International 64:185-190.

Boyde A, Jones SJ (1995) Mapping and measuring surfaces using reflection confocal microscopy. In: Handbook of Biological Confocal Microscopy, 2nd edition, pp255-266: JB Pawley (Ed) Plenum Press.

Boyde A (2008) Low kV and video-rate, beam-tilt stereo for viewing live-time experiments in the SEM. Chap. 7 pp. 197-214 and color plates 4-11. In: Schatten H, Pawley JB (eds) Biological Low Voltage Scanning Electron Microscopy, Springer New York.. ISBN 978-0-387-72970-1.

Boyde A (2003) The real response of bone to exercise. J Anat. 203:173-189.

Book chapters

Dental Histology and Clinical Applications

Boyde A (1963) The teeth of the skeletal remains of a child from Dinas Powys. In: Dinas Powys: Alcock LJ (Ed) University of Wales Press.

Boyde A (1964) The structure of developing mammalian dental enamel. In: Tooth Enamel pp163-167 & 192-194: Stack MV, Fearnhead RW (Eds) Wright, Bristol.

Boyde A (1965) The development of enamel structure in mammals. In: Calcified Tissues: Blackwood HJH, Owen M (Eds), Springer Verlag, Berlin, pp276-280.

Boyde A (1968) Dental histology of the ziphioid whales: a new calcified tissue (vasocementum). In: Les Tissues Calcifies pp383-386: Milhaud G, Owen M, Blackwood HJJ (Eds) Paris, Societe d'edition d'enseignement superieur.

Lester KS, Boyde A (1968) The surface morphology of some crystalline components of dentine. In: Dentine and Pulp pp197-219: Symons NBB (Ed) Livingstone, Edinburgh, Dundee.

Boyde A (1971) Comparative histology of mammalian teeth. In: Dental Morphology and Evolution,  Chapt 7, pp81-94: Dahlberg AA (Ed) Univ of Chicago Press.

Boyde A (1971) The Tooth Surface. In: The Prevention of Periodontal Disease, pp46-63: Eastoe JE, Picton DCA, Alexander AG (Eds), Henry Kimpton, London.

Boyde A (1971) Scanning electron microscopy of the completed enamel surface.  In: Tooth Enamel II, pp39-42: Fearnhead RW, Stack MV (Eds) Wright, Bristol.

Boyde A (1976) Amelogenesis and the structure of enamel. In: Scientific Foundations of Dentistry, Cohen B & Kramer IRH (Eds) pp335-352; William Heinemann Medical Books, London.

Boyde A (1978) Development of the structure of the enamel of the incisor teeth in the three classical subordinal groups of the rodentia. In: Butler PM, Joysey KA (Eds), Development, function and evolution of teeth, chapt 4, pp43-58,  Academic Press, London.

Boyde A (1980) Histological studies of dental tissues of odontocetes. In: Age determination of toothed whales and sirenians, Sci Rep Int Whaling Commission (Cambridge) Spec Issue 3:65-87.

Boyde A, Martin L (1984) The microstructure of primate dental enamel. In: Food Acquisition and Processing in Primates, pp341-367: Chivers DJ, Wood BA, Bilsborough A (Eds), Plenum Publishing Corporation, New York.

Boyde A, Martin L (1984) A non-destructive survey of prism packing patterns in primate enamels. In: Tooth Enamel IV, pp417-421: Fearnhead RW, Suga S (Eds) Elsevier, Amsterdam.

Boyde A, Lester KS (1984) Further SEM studies of marsupial enamel. In: Tooth Enamel I, pp442-446: Fearnhead RW, Suga S (Eds) Elsevier, Amsterdam.

Martin L, Boyde A (1984) Rates of enamel formation in relation to enamel thickness in hominoid primates. In: Tooth Enamel IV, pp447-451, Fearnhead RW, Suga S (Eds) Elsevier, Amsterdam.

Boyde A (1985) Anatomical considerations relating to tooth preparation. In: Resin Based Posterior Materials,  pp377-403: Smith D, Vanherle G (Eds) 3M Co., Minneapolis.

Jones SJ, Boyde A (1987) Dentine mineralization, demineralization & microhardness: recent studies using scanning microscopies. In: Dentine and Dentine Reactions in the Oral Cavity,  pp33-55: A Thylstrup, SA Leach and V Qvist (Eds) IRL Press, Oxford.

Jones SJ, Boyde A (1988) The resorption of dentine and cementum in vivo and in vitro. In: Biological Mechanisms of Tooth Eruption and Root Resorption pp335-354: Z Davidovitch (Ed) Ebsco Media, Birmingham AL.

Boyde A (1989) Enamel. In: Handbook of Microscopic Anatomy Vol V/6, pp309-473: A Oksche and L Vollrath (Eds) Springer Verlag, Berlin.

Boyde A (1990) Enamel. In: The Dentition and Dental Care,  pp30-48: RJ Elderton (Ed) Heinemann, London.

Boyde A (1990) Physical effects of clinical procedures on the hard dental tissues. In: The Dentition and Dental Care, pp325-347: RJ Elderton (Ed) Heinemann, London.

Boyde A (1990) Developmental interpretations of dental microstructure. In: Primate life history and evolution,  pp229-267: C Jean DeRousseau (Ed) Wiley-Liss, New York.

Boyde A (1997) Microstructure of enamel.  In: Dental enamel, pp18-31: (Ciba foundation symposium no. 205) Wiley, Chichester .

Jones  SJ, Boyde A (1999) Chapter 83. Development and Structure of Teeth and Periodontal Tissues. pp455-458 In:  MJ Favus (ed) Primer on the metabolic bone diseases and disorders of metabolism, Lippincott-Raven, Philadelphia

Boyde A (2008) Enamel Loss from Iatrogenic Demineralization Procedures. pp77-88  In: K.Kawasaki and JG Clement (Eds) Demineralization and Remineralization,  International Tooth Enamel Symposium, Wakaba Publishing Inc.Tokyo ISBN 978-4-89824-043-4..

Boyde A (2008) Low kV and video-rate, beam-tilt stereo for viewing live-time experiments in the SEM. Chap. 7 pp. 197-214 and color plates 4-11. In: Schatten H, Pawley JB (eds) Biological Low Voltage Scanning Electron Microscopy, Springer New York.. ISBN 978-0-387-72970-1.

Bone and Cartilage

Boyde A (1972) Scanning electron microscopic studies of bone. In: The Biochemistry and Physiology of Bone, 2nd edn, Vol.1, pp259-310 Bourne GH (Ed) Academic Press, New York.

Boyde A, Jones SJ (1972) Scanning electron microscopic studies of the formation of mineralised tissues. In: Developmental Aspects of Oral Biology pp243-273: Slavkin HC, Bavetta LA (Eds) Academic Press, New York.

Jones SJ, Boyde A, Ness AR (1976) SEM studies of osteoblasts: size, size-distribution and anisotropy in relation to hormonal status in organ culture. In: Bone Histomorphometry pp275-290: Meunier PJ (Ed) Armour-Montagu, Paris.

Boyde A (1976) Resolution, sampling and the determination of lacunar size. In: Bone Histomorphometry pp399-412: Meunier PJ (Ed). Armour-Montagu, Paris .

Boyde A, Banes AJ, Mechanic GL (1981) The association of MAV-2(0) virus with the mineralization process in chick bone. In: Matrix Vesicles pp97-102: Ascenzi A, Bonucci E, de Bernard B (Eds) Wichtig Editore srl, Rome.

Jones SJ,  Boyde A (1982) The junction between uncalcified and calcified cartilage. In: Current Advances in Skeletogenesis: development, biomineralisation, mediators and metabolic bone disease,  pp362-367: M.Silberman and HC Slavkin (Eds) Int Cong Ser 589 Excerpta Medica, Amsterdam.

Boyde A, Jones SJ, Ashford J (1982) Scanning electron microscope observations and the question of possible osteocytic bone mini-(re-) modelling. In: Current Advances in Skeletogenesis: development, biomineralisation, mediators and metabolic bone disease,  pp305-331: M.Silberman and HC Slavkin (Eds) Int Congr Ser 589 Excerpta Medica, Amsterdam.

Boyde A, Jones SJ (1983) Scanning electron microscopy of cartilage. In: Cartilage I: 105-148, Hall BK (Ed), Academic Press, New York.

Portigliatti-Barbos M, Bianco P, Ascenzi A, Boyde A (1985) Relationship between mechanical properties and distribution of lamellae in the human femoral shaft. In: Biomechanics: Current interdisciplinary research, pp173-178: SM Perren, E Schneider (Eds) Martinus Nijhoff, Dordrecht.

Bell LS, Boyde A, Jones SJ (1991) Backscattered electron imaging of diagenetic changes to teeth and related alveolar bone. In: Archaeological Science 1989: Proceedings of Conference on the Application of Scientific Techniques to Archaeology, Oxbow Monograph No. 9, pp345-351: Budd P, Chapman B, Jackson C, Janaway R & Ottaway B (Eds) Oxbow Books, Oxford.

Boyde A, Howell PGT, Bromage T, Elliott JC, Riggs CM, Bell LS, Kneissel M, Reid SA, Jayasinghe JAP, Jones SJ (1992) Applications of mineral quantitation of bone by histogram analysis of backscattered electron images. In: Chemistry and biology of mineralised tissues,  pp47-60: H Slavkin and P Price (Eds),  Excerpta Medica Int Congr Ser ICS 1002 Elsevier Science Publishers B.V.,  Amsterdam

Ascenzi A, Boyde A (1993) Micromechanical aspects of normal and deformed cortical bone. In: Micromovement in Orthopaedics, Oxford Medical Engineering Series 10, pp185-198: AR Turner-Smith (Ed);  Oxford Medical Publication, Clarendon Press, Oxford (1993).

Jones SJ, Piper K Vesely P, Gray C, Boyde A (1994) The significance of the size of an osteoclast. In: Biological Mechanisms of Tooth Eruption, Resorption, and Replacement by Implants, pp55-71: Z Davidovitch (Ed) Harvard Society for the Advancement of Orthodontics, Boston.

Jones SJ, Boyde A (1994) Skeletal connective tissues and Synovial joints, In:  Gray's Anatomy, 38th Ed, pp 443-484: R Soames (Ed) Churchill-Livingstone, Edinburgh.

Boyde A, Jones SJ (1998) Aspects of anatomy and development of bone. The nm, µm and mm hierarchy. In: Molecular and Cell Biology of Bone, M. Zaidi (Ed), Advances in Organ Biology Vol 5A, pp. 3-44, JAI Press Inc, Greenwich, Connecticut (publishers). ISBN: 0-7623-0390-5

Jones SJ, Boyde A, Gray C (1998) A testing time for osteoblasts: bone growth in vitro. In: Z. Davidovitch and J. Mah (eds), Biological Mechanisms Of Tooth Eruption, Resorption And Replacement By Implants. Harvard Society for the Advancement of Orthodontics, Boston Mass, pp 459-465.

VJ Kingsmill, SJ, Jones, A Boyde (1998) Mineralisation density of aged human mandibular bone. In: Z. Davidovitch and J. Mah (eds), Biological Mechanisms Of Tooth Eruption, Resorption And Replacement By Implants. Harvard Society for the Advancement of Orthodontics, Boston Mass, pp167-171.

Riggs CM, Boyde A (1999) Effect of  exercise on bone density in distal regions of the equine third metacarpal bone.  A study in 2 year old TBs. In: L.B. Jeffcott (ed) Equine Exercise Physiology 5, published by Equine Veterinary Journal Ltd, Newmarket pp 555-560.  ISSN 0425-1644.

Boyde A, Wolfe LA (2001) Spatial and Temporal Patterns of Bone Growth around Endosseous Implants: A Critical Study of Microscopic Methods. Chapter 29 pp 321-331 in Bone Engineering (ed. J.E. Davies), em squared Inc., Toronto, Canada.

Bromage TG, Boyde A (2008) Bone growth remodeling of the early human face. Chap. 17 pp.319-342 In: Enlow DH & Hans MG (eds), Essentials of Facial Growth, Second Edition. Needham Press, Ann Arbor. ISBN 978-1-60461-852-5.

Microscopical Methods and Techniques

Switsur VR, Boyde A (1963) A consideration of some design features of a scanning microanalyser for biological applications. In: X-ray optics and X-ray microanalysis pp495-497: Pattee HH, Cosslett VF, Engstrom A (Eds) Academic Press, New York.

Boyde A, Switsur VR (1963)  Problems associated with the preparation of biological specimens for  microanalysis. In: X-ray microanalysis and X-ray optics pp499-506: Pattee HH, Cosslett VE, Engstrom A (Eds) Academic Press, New York.

Boyde A (1974) Three-dimensional aspects of SEM images. chapter 11 pp277-336, In: Oliver C Wells (Ed), Scanning electron microscopy, McGraw-Hill book company, New York.

Boyde A, Jones SJ (1974) Bone and other hard tissues. In: Principles and techniques of scanning electron microscopy, Vol 2, chapt 10, pp123-149: Hayat MA(Ed); Van Nostrand Reinhold Co, New York.

Boyde A, Maconnachie E (1983) Not quite critical point drying. In: Science of Biological Specimen Preparation, pp71-75 : Revel JP, Barnard T, Haggis GH (Eds) SEM Inc, AMF O'Hare, IL, 1984.

Howell PGT, Boyde A (1984) Three-dimensional analysis of surfaces. In: The Analysis of Organic and Biological Surfaces, pp325-349: Echlin P (Ed), John Wiley and Sons Inc, New York.

Boyde A (1984) Methodology of calcified tissue specimen preparation for scanning electron microscopy. In: Methods of Calcified Tissue Preparation, pp251-307: Dickson GR (Ed), Elsevier, Amsterdam.

Jones SJ, Boyde A (1984) Scanning electron microscopy of tissues in biocompatibility testing. In: Techniques in Biocompatibility Testing I, pp131-148: Williams DF (Ed) CRC Press, Boca Raton, Florida.

Petran M, Hadravsky M, Boyde A, Müller M (1985) Tandem Scanning  Reflected Light Microscopy. In: Science of Biological Specimen Preparation,  pp85-94: M Muller, RP Becker, A Boyde, J Wolosewick (Eds) SEM Inc, AMF O'Hare (Chicago) IL.

Boyde A (1990) Confocal Optical Microscopy. In: Modern Microscopies: Techniques and Applications, pp185-204: PJ Duke and AG Michette (Eds) Plenum, New York.

Boyde A (1990) Direct recording of stereoscopic pairs from the disk scanning confocal light microscopes. In:  The Handbook of Biological Confocal Microscopy, pp163-168: JB Pawley (Ed) Plenum Press, New York.

Petran M, Hadravsky M, Boyde A (1990) Direct view confocal microscopy. In: Confocal Microscopy,  pp245-283: T Wilson (Ed) Academic Press, London.

Elliott JC, Anderson P, Davis GR, Wong FSL, Gao XJ, Dover SD, Boyde A (1992) X-ray microtomographic studies of bones and teeth. In: X-ray Microscopy III (Springer Series in Optical sciences, Vol 67) pp 461-464: A Michette, G Morrison & C Buckley (Eds)  Springer-Verlag, Berlin.

Boyde A (1992) Bulk specimen freeze-drying. Module 11:3 pp 11.3.1-11.3.13. Stereoscopic observation. Module 14:12 pp 14:12.1-14:12.5. In: Protocols in Electron Microscopy: AW Robards and AJ Wilson (Eds) Wiley, Chichester.

Boyde A (1993) Real-time direct-view confocal light microscopy. In:  Electronic Light Microscopy: The principles and practice of video-enhanced contrast, digital intensified fluorescence, and confocal scanning light microscopy, pp289-314: D Shotton (Ed) Wiley-Liss, New York.

Boyde A (1993) Aspects of 3-D imaging, display and measurement in light and scanning electron microscopy. In:  X-RAY OPTICS AND MICROANALYSIS 1992: Inst Phys Conf Ser No. 130, pp353-360: Kenway PB et al (Eds) IOP Publishing Ltd, Bristol.

Boyde A (1993) In memory of VE Cosslett: from scanning with electrons to scanning with light in the investigation of mineralised tissues. In: X-RAY OPTICS AND MICROANALYSIS 1992: Inst Phys Conf Ser No. 130, 53-58: Kenway PB et al (Eds)  IOP Publishing Ltd, Bristol.

Boyde A, Wolfe LA, Jones SJ (1994) Microscopic methods of special relevance to the examination of bone and the implant interface. In: Imaging Techniques in Biomaterials, pp143-172: MA Barbosa and A Campilho (Eds) Elsevier, Amsterdam.

Boyde A, Gray C, Jones SJ (1994) Real time confocal microscopy and cell biology. In: Cell Biology: A laboratory Handbook, pp96-101:  JE Celis (Ed) Academic Press, San Diego.

Boyde A (1995) Confocal optical microscopy. In:  Image Analysis in Histology: conventional and confocal microscopy,  pp151-196: Wootton R, Springall DR, Polak JM (Eds) Cambridge University Press, Cambridge  ISBN 0-521-43482-3(hc).

Boyde A, Jones SJ (1995) Mapping and measuring surfaces using reflection confocal microscopy. In: Handbook of Biological Confocal Microscopy, 2nd edition, pp255-266: JB Pawley (Ed) Plenum Press.

Vesely P, Boyde A (1996) Video Rate Confocal Laser Scanning Reflection Microscopy in the Investigation of Normal and Neoplastic Living Cell Dynamics In: The Science of Biological Specimen Preparation for Microscopy, Scanning Microscopy Supplement 10, 201-212  ISSN: 0892-953X  publ. by Scanning Microscopy International, AMF O'Hare (Chicago), IL 60666, USA

Greenberg G, Boyde A (1999) Multiple oblique illumination method of high definition stereo microscopy. pp 1-24. In: Focus on Modern Microscopy, PC Cheng (Ed), World Scientific Publishing Co. Pte. Ltd. Singapore-New Jersey-London-Hong Kong ISBN  981-02-3053-2.

Greenberg G, Boyde A (2002) Three-dimensional microscopy. Chapter 3, pp51-76 In: JA Kiernan and I Mason (eds) Microscopy and Histology for Molecular Biologists, Portland Press, London. ISBN 1 85578 141 7

Boyde A (2004) A.D.G. Stewart and an Early Biological Application of the Scanning Electron Microscope. pp. 165-174 In: BC Breton, D McMullan and KCA Smith (eds) Advances in Imaging and Electron Physics Vol 113 Sir Charles Oatley and the Scanning Electron Microscope. Elsevier Academic Press, Amsterdam ISBN: 0-12-014775-0.

Bromage TG, Boyde A, Perez-Ochoa A (2004) Nuevas posibilidades en la investigación Palaeantropologica utilizando un microscopio confocal patátil. In: Zona Arqueologócia, Número 4, Miscelánea en homenaje a Emilio Aguirre, Volumen III Palaeoantropologia, Eds E. Baquedano & S. Rubio Jara. Publisher - Museo Arqueológica Regional. City – Alcalá de Henares.  ISBN 84-451-2655-5.

Boyde A (2012)  Scanning Electron Microscopy of Bone, Chap 24 In: MH Helfrich and SH Ralston (eds.), Bone Research Protocols, Methods in Molecular Biology, vol. 816, DOI 10.1007/978-1-61779-415-5_24, Springer Science+Business Media, LLC. Methods Mol Biol. 2012;816:365-400.

PhD Supervision

Public engagement

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