Dr Anwar Tappuni, BDS, LDSRCS, PhD, MRACDS (OM), FHEA
Reader/Honorary Consultant in Oral Medicine
Email: email@example.comTelephone: +44 20 7882 8655Room Number: Office 7, Floor 4, Institute of Dentistry
Anwar R Tappuni is the Academic Lead for Oral Medicine, Centre for Immunobiology and Regenerative Medicine, Institute of Dentistry. She is Honorary Professor at the School of Dentistry, Saveetha University, Chennai, India. Anwar has several high profile international and national roles including the President of the Oral Medicine and Pathology Group of the International Association for Dental Research and of the British Society for Oral and Dental Research, Chair of the BMA/BDA Refugee Doctors and Dentists Liaison Group and Member of the BDA Central Committee for Dental Academic.
She is on the Medical Council and a Trustee for the British Sjögren’s Syndrome Association. Anwar leads a successful multidisciplinary clinic with rheumatology consultants, providing specialised clinical service for Sjögren’s syndrome patients. She has co-authored the National Management Guidelines for Adults with Sjögren’s Syndrome, approved by NICE, the British Society for Rheumatology and The British Health Professionals in Rheumatology (Price et al 2017).
Anwar co-chaired the International Steering Committee and the meeting of the 7th World Workshop for Oral Health and Disease in AIDS in 2014 in Hyderabad, India. She was a guest editor of a Supplement of Oral Diseases for the Conference Proceedings and the first author of the Research Agenda for Oral HIV/AIDS paper (Tappuni and Shiboski 2016). She has developed and published a clinical tool for assessing severity of oral ulcerative disease, which has been adopted for use in several clinical units and employed in clinical trials. Anwar has been awarded the BDA Roll of Distinction for outstanding service to UK dentistry.
ReSjögren’s syndrome, dry mouth, smell and taste impairment, mucosal disease severity scoring.
Fisher BA, Everett CC, Rout J, O'Dwyer JL, Emery P, Pitzalis C, Ng W-F, Carr A, Pease CT, Price EJ, Sutcliffe N, Makdissi J, Tappuni AR, et al. Effect of Rituximab on a Salivary Gland Ultrasound Score in Primary Sjögren's Syndrome: results of the TRACTISS randomised double-blind multicentre substudy. Ann Rheum Dis online ahead of publication 23 Dec 2017 (Journal IF 12.8).
Price E, Rauz S, Tappuni A, Sutcliffe N, Hackett KL, Barone F, Granata G, Ng W, Fisher BA, Bombardieri M, Astorri E, Empson B, Larkin G, Crampton B, Bowman S. BSR and BHPR Guideline for the Management of Adults with Primary Sjögren’s Syndrome. Journal of Rheumatology 2017; 56 (10): e24-e48. (Journal IF 4.8).
Price E, Rauz S, Tappuni A, Sutcliffe N, Hackett KL, Barone F, Granata G, Ng W, Fisher BA, Bombardieri M, Astorri E, Empson B, Larkin G, Crampton B, Bowman S. BSR and BHPR Guideline for the Management of Adults with Primary Sjögren’s Syndrome. Executive Summary. Journal of Rheumatology. 2017; 56 (10): 1643-1647. (Journal IF 4.8).
Fisher BA, Jonsson R, Daniels T, Bombardieri M, et al. Standardisation of labial salivary gland histopathology in clinical trials in primary Sjögren's syndrome. Ann Rheum Dis 2017; 76(7):1161-1168. (Journal IF 12.8)
Tappuni AR, Al-Kaabi R, Joury E. Effect of Free Sugars on Diabetes, Obesity, and Dental Caries. Letter to the editor. J Dent Res 2016; 96 (1): 116-116.
Joury E, Al-Kaabi R, Tappuni AR. Constructing Public Health Policies in Post Crisis Countries: Lessons to Learn From The Associations Between Free-Sugars Consumption and Diabetes, Obesity and Dental Caries Before, During and After Sanctions in Iraq. J Public Health 2016; 24:563–569.
Tappuni AR, Shiboski C. Overview and Research Agenda Arising From The 7th World Workshop on Oral Health and Disease in AIDS. Oral Diseases 2016; S1 22:211-214.
Mothi SN, Lala MM, Tappuni AR. HIV/AIDS in Women and Children in India. Oral Diseases 2016; S1 22:19-24.
Challacombe SJ, Tappuni AR, Ranganathan K et al. Hyderabad Declaration 2014. Oral Diseases 2016; S1 22: 7-7.
Kumarasamy N, Ranganathan K, Tappuni AR et al. Suniti Solomon, Founder-Director Y.R. Gaitonde Centre for AIDS Research and Education (YRG CARE).Oral Diseases 2016; S1 22: 8-9.
Challacombe SJ, Tappuni AR, Ranganathan K. The Mouth and AIDS: lessons learned and emerging challenges in global oral health. Oral Diseases 2016; S1 22: 5-6.
Astorri E, Sutcliffe N, Richards PS, Suchak K, Pitzalis C, Bombardieri M, Tappuni AR. Ultrasound of the Salivary Glands is a Strong Predictor of Labial Gland Biopsy Histopathology in Patients With Sicca Symptoms. Journal of Oral Pathology and Medicine. 2016; 45 (6) 450-454.
Amin K, Willis A, Plowman N, Tappuni AR et al. A case of an unusual palatal lymphoma. International Journal of Oral and Maxillofacial Surgery. 2015; S1 44:e86-e186.
Challacombe SJ, Alsahaf S, Tappuni AR. Recurrent Aphthous Stomatitis: Towards Evidence-Based Treatment. Current Oral Health Reports. 2015; 2 (3):158-167.
Vartoukian SR, Tilakaratne W, Seoudi N, Bergmeier L, Tappuni AR, Fortune F. Dysregulation of the SOCS3-STAT3 pathway in the aetio-pathogenesis of Sjögren’s syndrome. Clinical and Experimental Immunology. 2014; 177 (3) 618-629.
Croia C, Astorri E, Murray-Brown W, Willis A, Brokstad KA, Sutcliffe N, Piper K, Jonsson R, Tappuni AR, Pitzalis C, Bombardieri M. Implication of Epstein-Barr Virus Infection in Disease-Specific Autoreactive B Cell Activation in Ectopic Lymphoid Structures of Sjögren's Syndrome. Arthritis Rheumatol. 2014; 66 (9) 2545-2557.
Lakhani S, Barnett S, Tappuni AR et al. Recurrent Lip Swelling: a Diagnostic Challenge. British Medical Journal. Case Rep 2014; 10.1136/bcr-2013-20301
Tappuni AR, Kovacevic T, Shirlaw PJ, Challacombe SJ. Clinical Assessment of Disease Severity in Recurrent Aphthous Stomatitis. Journal of Oral Pathology and Medicine. 2013; 42 (8) 635-641.
Tappuni AR, Tbakhi A, Sharquie KE, Hayani RK, Al-Kaisi A, Lafi A, Al-Araj A. A Comparative Study of the Genetics of Behcet's Disease in Iraq. Med Confl Surviv, 2013; 29 (1): 57-68.
Tappuni AR, Kovacevic T, Shirlaw, PJ, Challacombe SJ. Clinical Assessment of Disease Severity in Recurrent Aphthous Stomatitis. Journal of Oral Pathology and Medicine. 2013; 42 (8): 635-41.
Ramirez-Amador V, Nittayananta W, Magalhães M, Flint SR, Peters BS, Tappuni AR. Clinical Markers of Immunodeficiency and Mechanism of Immune Reconstitution Inflammatory Syndrome and Highly Active Antiretroviral Therapy. Adv Dent Res, 2011; 23 (1): 165-171.
Papagatsia Z, Jones J, Morgan P, Tappuni A. Oral Kaposi Sarcoma: a Case of Immune Reconstitution Inflammatory Syndrome. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2009; 108 (1): 70-75.
Naglik JR, Moyes D, Makwana J, Kanzaria P, Tsichlaki E, Weindl G, Tappuni AR, Rodgers CA, Woodman AJ, Challacombe SJ, Schaller M, Hube B. Quantitative Expression of the Candida Albicans Secreted Aspartyl Proteinase Gene Family in Human Oral and Vaginal Candidiasis. Microbiology, 2008; 154: 3266-80.
Papagatsia Z, Tappuni A, Watson R J, Cook T F. Single Wavelength Micro-Endoscopy in Non-Surgical Vascular Lesion Diagnosis and Characterization. Journal of Microscopy, 2008; 230(2): 203-11.
Escudier M, Ahmed N, Shirlaw P, Setterfield J, Tappuni A, Black M, Challacombe SJ. A Novel Scoring System for Mucosal Disease: Application to Oral Lichen Planus. British Journal of Dermatology, 2007; 157 (4): 765-770.
Chiandussi S, Tappuni AR, Watson TF, White A, Escudier M, Sanderson JD, Challacombe SJ. Assessment of Morphological Changes of the Lips in Patients with Orofacial Granulomatosis: A New Technique Using Lip Impressions. Oral Diseases, 2007; 13 (1): 93–98.
Flint SR, Tappuni A, Leigh J, Schmidt-Westhausen AM, MacPhail L. Markers of Immunodeficiency and Mechanisms of HAART Therapy on Oral Lesions. Adv Dent Res, 2006; 19: 146-151.
Tappuni AR, Kovacevic T, Shirlaw PJ, Challacombe SJ. Clinical Assessment of Disease Severity in Recurrent Aphthous Stomatitis. Oral Biosci Med, 2005; 2: 5-13.
Flint S, Glick M, Patton L, Tappuni A, Shirlaw P, Robinson P. Consensus guidelines on quantifying HIV-related Oral Mucosal Disease. Oral Diseases 8 Suppl, 2002; 2: 115-9.
Tappuni AR, Fleming GJ. The effect of antiretroviral therapy on the prevalence of oral manifestations in HIV-infected patients: a UK study. Oral Surgery Oral Medicine Oral Pathology Oral Radiology & Endodontics, 2001; 92 (6): 623-8.
Chaudhry SI, Tappuni AR, Challacombe SJ. Multiple Maxillary and Mandibular Exostoses Associated with Multiple Dermatofibromas: a case report. Oral Surgery Oral Medicine Oral Pathology Oral Radiology & Endodontics, 2000; 89 (3): 319-22.
Makarova N, Yurin O, Pokrovsky V, Tappuni AR. Infections in Hospitalised Russian Children with AIDS. Oral Diseases 3 Suppl, 1997; 1: S119-21.
Tappuni AR, Challacombe SJ. A Comparison of Salivary Immunoglobulin A (IgA) and IgA Subclass Concentrations in Predentate and Dentate Children and Adults. Oral Microbiology & Immunology, 1994; 9 (3): 142-5.
Tappuni AR, Challacombe SJ. Distribution and Isolation Frequency of Eight Streptococcal Species in Saliva from Predentate and Dentate Children and Adults. Journal of Dental Research, 1993; 72 (1): 31-6.
Tappuni AR and Tilakaratne WM, Oral Manifestations of Systemic Disease. In Oral Medicine and Pathology: A Guide to Diagnosis and Management. 563 pages. 2014. Jaypee Brothers Publishers. First Edition.
Tappuni AR. A lump on the gingiva. In EW Odell (Ed), Clinical problem solving in dentistry. Churchill Livingstone. First edition 2000, Second edition 2009, third edition 2013, fourth edition electronic publication. 288 pages.
Tappuni AR. Other Dental and Oral Problems. In S Rankin Manual for Oral Health. 2007, 100 pages.
Al-Ezzi MY, Pathak N, Tappuni AR, Khan KS. Primary Sjögren's Syndrome Impact on Smell, Taste, Sexuality and Quality of life in Female Patients: a systematic review and meta-analysis. Mod Rheumatol. Nov 2016. 1-17 20 [Epub ahead of print]
Tappuni AR. Immune Reconstitution Inflammatory Syndrome. Ad Dent Res: 2011; 23 (1): 90-96.
Javed F, Correa FO, Chotai M, Tappuni AR, Almas K. Systemic Conditions Associated with Areca Nut Usage: a literature review. Scand J Public Health, 2010; 38 (8): 838-844.
Moutasim K, Tappuni AR., Current concepts in the pathogenesis and management of oral mucositis as a complication of cancer therapy. Journal of Disability and Oral Health, 2008; 9 (1): 17-26.
Published abstracts 2012-2017
Pontarini E, Murray-Brown W, Croia C, Astorri E, Lucchesi D, Lepse N, Sutcliffe N, Tappuni A, Pitzalis C, Bombardieri M. Enrichment of T Follicular-Helper Cells (TFH) And Exclusion Of T Follicular-Regulatory Cells from Ectopic Germinal Centers in Salivary Glands Of Sjögren’s Syndrome Patients. Annals of the Rheumatic Diseases 2017; 76:180.
Murray-Brown W, Carlotti E, Floyd J, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Mehr R, Pitzalis C, Bomabardieri M European Journal Of Immunology. 2016; 46: 939-940.
Murray-Brown W, Carlotti E, Floyd J, Sutcliffe N, Tappuni A, Vartoukian S, Bobardieri M. Next-Generation sequencing demonstrates dynamic recirculation of B cell clones in ectopic lymphoid structures of Sjögren's Syndrome. Annals of the Rheumatic Diseases 2015; 74 (Suppl 2), 425-426.
Amin K, Willis A, Plowman N, Jawad A, Bombardieri M, Tappuni A, A Case Of an Unusual Palatal Lymphoma. International Journal of Oral and Maxillofacial Surgery. 2015; 44: e186
Murray-Brown W, Carlotti E, Floyd J, Sutcliffe N, Tappuni A, Vartoukian S, Bombardieri M. Next-Generation Sequencing Demonstrates Dynamic Recirculation of B Cell Clones in Ectopic Lymphoid Structures of Sjögren’s Syndrome. Scandinavian Journal of Immunology. 2015; 81:401-402.
Astorri E, Croia C, Picarelli G et al. Routine Investigations for Circulating IgG4 and/or IgG4+Salivary Gland Histopathology Fail to Reveal Undiagnosed Cases of IgG4 Related Disease in Sicca Patients not Fulfilling the Diagnosis of Sjögren’s Syndrome. Scandinavian Journal of Immunology. 2015. 81: 341-341.
Astorri E, Tappuni A, Sutcliffe N, Richards P, Pitzalis C, Bombardieri M. A Negative High-resolution Salivary Gland Ultrasound is Highly Predictive of Negative Labial Gland Biopsy in Patients with Sicca Symptoms. Annals of the Rheumatic Diseases. 2014; 73: 179-179.
Croia C, Serafini B, Tappuni A, Aloisi F, Sutcliffe N, Pitzalis C, Bombardieri M. Ectopic Lymphoid Structures Support Epstein-Barr Virus Persistence and Autoreactive Plasma Cell Infection in Sjögren’s Syndrome Salivary Glands. EULAR; Annals of the Rheumatic Diseases 2013; 72, 462-462.
Murray-Brown W, Croia C, Sutcliffe N, Tappuni A, Pitzalis C, Bombardieri M. Lesional Intereukin-21 Expression Correlates with Functional Germinal Center Formation and T Follicular Helper Cell Infiltration in the Salivary Glands of Sjögren’s Syndrome. Arthritis and Rheumatism. 2013; 65:S634-S634.
Murray-Brown W, Croia C, Sutcliffe N, Anwar Tappuni et al. Lesional IL-21 Expression Correlates With Functional Germinal Center Formation And T Follicular Helper Cell Infiltration In The Salivary Glands of Sjögren’s Syndrome. Immunology. 2012; 137:491-491.
Alsahaf S, Tappuni AR, Challacombe SJ. Management of Recurrent Aphthous Stomatitis with Colchicine and Betnesol Mouthwash. Oral Diseases. 2012; 18: 30-30.
She is currently supervising two PhD projects; one investigating smell, taste and sexual function in Sjögren’s patients and the other is a double-blind placebo controlled trial of the efficacy of a dental varnish in treating root caries in dry mouth patients. She is also a co-investigator in two industry-funded clinical trials for treatment modalities for Sjögren’s Syndrome. PhD opportunities are available in the subjects of Sjögren’s syndrome and Oral manifestations of HIV.