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Institute of Dentistry

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Dr Pete Tomlins, BSc (Hons), PhD, CPhys, MInstP

Pete

Senior Lecturer in Oral Biometrics

Email: p.h.tomlins@qmul.ac.uk
Telephone: 020 7882 8626
Room Number: Office 4, 4th Floor, Dental Hospital, Whitechapel

Profile

Dr Tomlins is an academic member of staff within the Imaging Group and Centre for Oral Bioengineering.  He completed his first degree in Physics at Lancaster University (UK) and PhD in Biomedical Optics at Cranfield University (UK).  In 2002 he joined the UK's National Physical Laboratory (NPL) working in the fields of fibre optic telecoms, refractive index measurement and biophotonics.  From 2006-2010, Dr Tomlins led NPL’s biophotonics group, developing standards for biomedical imaging with optical coherence tomography (OCT).  In 2009 Pete was appointed as an Honorary Senior Lecturer in Dental Biomaterials at Birmingham University’s Dental School and in August 2010 he took up his current post at Queen Mary University of London to continue development of OCT as a clinical tool in dentistry.

Dr Tomlins is a Chartered Physicist of the Institute of Physics (IoP) and Treasurer of the IoP Optical Group.

Teaching

I teach the Statistics for Research Component of the Fundamentals of Research Module for all taught post-graduate students.

Additionally I supervise MSc projects from the Institute of Dentistry and BEng projects from the School of Electronic Engineering and Computer Science.

Research

Research Interests:

ptomlins graphic

My research revolves around using light to non-invasively measure biological tissue.  I am particularly interested in an imaging technique called optical coherence tomography (OCT) and using it to understand oral diseases of hard and soft tissue.  Conditions of interest include, oral epithelial dysplasia, periodontal inflammation, caries and erosion.

I collaborate closely with researchers in the School of Electronic Engineering and Computer Science to develop new algorithms by which OCT data can be analysed to provide diagnostic information.  Recent advances include the use of OCT to image micro-vasculature by locking on to the heart beat.  We have also measured the complex curing dynamics of dental composite materials.

My current activity now focusses on translating these laboratory based studies into clinical use.

Publications

Journal Publications

Lopez-Tremoleda, J., Alvarez, K., ADEN, A., DONNAN, R. S., MICHAEL-TITUS, A. T., & TOMLINS, P. H. (2017). Heart-rate sensitive optical coherence angiography for measuring vascular changes due to posttraumatic brain injury in mice. Journal of Biomedical Optics, 22(12), 121710. doi:10.1117/1.JBO.22.12.121710

TOMLINS, P. H., Anthony, A., Brigi, C., Merchant, M., Siraj, H., & Aden, A. (2017). Dynamic measurement of the optical properties of bovine enamel demineralization models using 4D Optical Coherence Tomography. Journal of Biomedical Optics, 22(7). doi:10.1117/1.JBO.22.7.076020

Ud Din, S., Parker, S., Braden, M., Tomlins, P., & Patel, M. (2017). Experimental hydrophilic vinyl polysiloxane (VPS) impression materials incorporating a novel surfactant compared with commercial VPS.. Dent Mater. doi:10.1016/j.dental.2017.04.012

TOMLINS, P. H., Aden, A., Anderson, P., Lynch, J. M., & Burnett, G. (2017). Longitudinal correlation of 3D OCT to detect early stage erosion in bovine enamel. Biomedical Optics Express, 8(2), 954-973. doi:10.1364/BOE.8.000954

DONNAN, R. S., Tomlins, P. H., & Rahman, M. W. (2016). Dynamic measurement of local displacements within curing resin based dental composite using optical coherence elastography. Journal of Biomedical Optics, 21(4), 046001-1-046001-5. doi:10.1117/1.JBO.21.4.046001

TOMLINS, P. H., Agrawal, A., Pfefer, T. J., Woolliams, P. D., & Nehmetallah, G. (n.d.). Methods to Assess Sensitivity of Optical Coherence Tomography Systems. Biomedical Optics Express, 8(2). doi:10.1364/BOE.8.000902

Fouad, A., Pfefer, T. J., Chen, C. -W., Gong, W., Agrawal, A., Tomlins, P. H., . . . Chen, Y. (2014). Variations in optical coherence tomography resolution and uniformity: a multi-system performance comparison.. Biomed Opt Express, 5(7), 2066-2081. doi:10.1364/BOE.5.002066

Adegun, O. K., TOMLINS, P. H., Hagi-Pavli, E., Bader, D. L., & Fortune, F. (2013). Quantitative optical coherence tomography of fluid-filled oral mucosal lesions. Lasers in Medical Science, 28(5), 1249-1255. doi:10.1007/s10103-012-1208-y

Adegun, O. K., Tomlins, P. H., Hagi-Pavli, E., Bader, D. L., & Fortune, F. (2013). Quantitative optical coherence tomography of fluid-filled oral mucosal lesions.. Lasers Med Sci, 28(5), 1249-1255. doi:10.1007/s10103-012-1208-y

Adegun, O. K., Tomlins, P. H., Hagi-Pavli, E., McKenzie, G., Piper, K., Bader, D. L., & Fortune, F. (2011). Quantitative analysis of optical coherence tomography and histopathology images of normal and dysplastic oral mucosal tissues.. Lasers Med Sci, 1-10. doi:10.1007/s10103-011-0975-1

Woolliams, P. D., & Tomlins, P. H. (2011). Estimating the resolution of a commercial optical coherence tomography system with limited spatial sampling. MEASUREMENT SCIENCE AND TECHNOLOGY, 22(6). doi:10.1088/0957-0233/22/6/065502

Woolliams, P. D., & Tomlins, P. H. (2011). The modulation transfer function of an optical coherence tomography imaging system in turbid media.. Phys Med Biol, 56(9), 2855-2871. doi:10.1088/0031-9155/56/9/014

Tomlins, P. H., Smith, G. N., Woolliams, P. D., Rasakanthan, J., & Sugden, K. (2011). Femtosecond laser micro-inscription of optical coherence tomography resolution test artifacts. Biomed. Opt. Express, 2, 1319-1327. doi:10.1364/BOE.2.001319

Rasakanthan, J., Sugden, K., & Tomlins, P. H. (2011). Processing and rendering of Fourier domain optical coherence tomography images at a line rate over 524 kHz using a graphics processing unit. JOURNAL OF BIOMEDICAL OPTICS, 16. doi:10.1117/1.3548153

Tomlins, P. H., Smith, G. N., Woolliams, P. D., Rasakanthan, J., & Sugden, K. (2011). Femtosecond laser micro-inscription of optical coherence tomography resolution test artifacts.. Biomed Opt Express, 2(5), 1319-1327. doi:10.1364/BOE.2.001319

Tomlins, P. H., Adegun, O., Hagi-Pavli, E., Piper, K., Bader, D., & Fortune, F. (2010). Scattering attenuation microscopy of oral epithelial dysplasia. Journal of Biomedical Optics, 15(6). doi:10.1117/1.3505019

Grimwood, A., Garcia, L., Bamber, J., Holmes, J., Woolliams, P., Tomlins, P., & Pankhurst, Q. A. (2010). Elastographic contrast generation in optical coherence tomography from a localized shear stress. Phys. Med. Biol., 55, 5515-5528. doi:10.1088/0031-9155/55/18/016

Hadis, M. A., Tomlins, P. H., Shortall, A. C., & Palin, W. M. (2010). Dynamic monitoring of refractive index change through photoactive resins.. Dent Mater, 26(11), 1106-1112. doi:10.1016/j.dental.2010.07.011

Woolliams, P. D., Ferguson, R. A., Hart, C., Grimwood, A., & Tomlins, P. H. (2010). Spatially deconvolved optical coherence tomography.. Appl Opt, 49(11), 2014-2021. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/20389999

Tomlins, P. H., Woolliams, P., Hart, C., Beaumont, A., & Tedaldi, M. (2008). Optical coherence refractometry.. Opt Lett, 33(19), 2272-2274. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18830375

Tomlins, P. H., & Wang, R. (2007). Digital phase stabilization to improve detection sensitivity for optical coherence tomography. MEASUREMENT SCIENCE AND TECHNOLOGY, 18(11), 3365-3372. doi:10.1088/0957-0233/18/11/016

Tomlins, P. H., Palin, W. M., Shortall, A. C., & Wang, R. K. (2007). Time-resolved simultaneous measurement of group index and physical thickness during photopolymerization of resin-based dental composite.. J Biomed Opt, 12(1), 014020. doi:10.1117/1.2709877

Tomlins, P. H., & Wang, R. K. (2006). Simultaneous analysis of refractive index and physical thickness by Fourier domain optical coherence tomography. IEE PROCEEDINGS-OPTOELECTRONICS, 153(5), 222-228. doi:10.1049/ip-opt:20050115

Tomlins, P. H., & Wang, R. K. (2006). Matrix approach to quantitative refractive index analysis by Fourier domain optical coherence tomography.. J Opt Soc Am A Opt Image Sci Vis, 23(8), 1897-1907. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/16835647

Tomlins, P. H., & Wang, R. K. (2005). Theory, developments and applications of optical coherence tomography. JOURNAL OF PHYSICS D-APPLIED PHYSICS, 38(15), 2519-2535. doi:10.1088/0022-3727/38/15/002 

Conference Proceedings

Sandrian, M. G., Tomlins, P., Woolliams, P., Rasakanthan, J., Lee, G. C. B., Yang, A., . . . Drexler, W. (2012). Three-dimensional calibration targets for optical coherence tomography. In OPTICAL DIAGNOSTICS AND SENSING XII: TOWARD POINT-OF-CARE DIAGNOSTICS AND DESIGN AND PERFORMANCE VALIDATION OF PHANTOMS USED IN CONJUNCTION WITH OPTICAL MEASUREMENT OF TISSUE IV Vol. 8229. doi:10.1117/12.907748

Beaumont, A., Hu, M., & Tomlins, P. H. (2010). Understanding the nature of optical coherence tomography images using Monte Carlo modeling. In OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE IV Vol. 7566. doi:10.1117/12.841893

Woolliams, P. D., & Tomlins, P. H. (2010). Contrast phantoms for optical coherence tomography. In DESIGN AND PERFORMANCE VALIDATION OF PHANTOMS USED IN CONJUNCTION WITH OPTICAL MEASUREMENT OF TISSUE II Vol. 7567. doi:10.1117/12.841863

Tedaldi, M., Woolliams, P., Hart, C., Beaumont, A., & Tomlins, P. (2009). Refractive index mapping of layered samples using optical coherence refractometry. In MULTIMODAL BIOMEDICAL IMAGING IV Vol. 7171. doi:10.1117/12.809090

Tomlins, P. H., Woolliams, P., Tedaldi, M., Beaumont, A., & Hart, C. (2008). Measurement of the three-dimensional point-spread function in an optical coherence tomography imaging system - art. no. 68472Q. In COHERENCE DOMAIN OPTICAL METHODS AND OPTICAL COHERENCE TOMOGRAPHY IN BIOMEDICINE XII Vol. 6847 (pp. Q8472). doi:10.1117/12.766576

Tomlins, P. H., Palin, W. M., & Shortall, A. C. (2008). Dynamic cure measurement of dental polymer composites using optical coherence tomography. In LASERS IN DENTISTRY XIV Vol. 6843. doi:10.1117/12.763305

Tomlins, P. H., Wang, Y., Zhang, B., Tedaldi, M., & Tomlins, P. E. (2008). Complex flow characterisation of a porous tissue scaffold measured by Doppler optical coherence tomography. In OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE II Vol. 6858. doi:10.1117/12.761772

Tomlins, P. H., Tedaldi, M., Ferguson, R. A., & Wang, R. K. (2007). Stereoscopic optical coherence tomography in the frequency domain for refractive index sensitive imaging. In OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE TECHNIQUES III Vol. 6627. doi:10.1117/12.728040

Tomlins, P. H., & Wang, R. K. (2006). Layer dependent refractive index measurement by Fourier domain optical coherence tomography. In COHERENCE DOMAIN OPTICAL METHODS AND OPTICAL COHERENCE TOMOGRAPHY IN BIOMEDICINE X Vol. 6079. doi:10.1117/12.645719

Wang, R. K., Cheung, S., Tomlins, P. H., Chong, C., Morosawa, A., & Heard, D. (2006). High speed frequency swept light source at 1550nm for Fourier domain OCT with A-scanning rate at 20kHz. In COHERENCE DOMAIN OPTICAL METHODS AND OPTICAL COHERENCE TOMOGRAPHY IN BIOMEDICINE X Vol. 6079. doi:10.1117/12.648726

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