Dr Natalia Karpukhina, PhD
Lecturer in Dental Physical Sciences
Nov 2009 – present
Lecturer, Centre for Oral Growth and Development,
Barts and The London School of Medicine and Dentistry,
Queen Mary University of London
May 2007 – Oct 2009
Post Doctoral Research Associate, Department of Chemistry,
Department of Materials, Imperial College London
Nov 2005 – Apr 2007
Post Doctoral Research Associate, Department of Chemistry,
Dalhousie University, Halifax, Canada
Jun 2004 – Jun 2005
Guest Scientist, Max-Planck Institute for Metals Research, Stuttgart, Germany
Dec 2001 – May 2004
Post Doctoral Research Associate, Department of Physical Chemistry,
St.Petersburg State University, St.Petersburg, Russia
Nov 2001 PhD in Physical Chemistry
Department of Physical Chemistry,
St.Petersburg State University, St.Petersburg, Russia
Publications:
Key publications
O’Donnell MD, Hill RG, Karpukhina N, Law RV. Real time neutron diffraction and NMR of the Empress II glass-ceramic system. Dental Mater (2011) 27:990-996
Abo-Mosallam HA, Hill RG, Karpukhina N, Law RV. MAS-NMR studies of glasses and glass-ceramics based on a clinopyroxene-fluoroapatite system, J Mater Chem (2010) 20:790-797
Munhoz T, Karpukhina N, Hill RG, Law RV. Setting of commercial glass ionomer cement Fuji IX by 27Al and 19F MAS-NMR. J Dent (2010) 38:325-330
Brauer DS, Karpukhina N, O’Donnell MD, Law RV, Hill RG. Fluoride-containing bioactive glasses: Effect of glass design and structure on degradation, pH and apatite formation in simulated body fluid. Acta Biomater (2010) 6:3275-3282
Hill RG, O’Donnell MD, Law RV, Karpukhina N, Cochrane B, Tulyaganov D. The early stages of nucleation and crystallisation of an apatite glass-ceramic: Evidence for nano-scale crystallisation. J Non-Cryst Solids (2010) 356:2935-2941
Brauer DS, Karpukhina N, Law RV, Hill RG. Structure of fluoride-containing bioactive glasses. J Mater Chem (2009) 19:5629-5636
Publications since 2006
Lynch E, Brauer DS, Karpukhina N, Gillam DG, Hill RG. Multi-component bioactive glasses of varying fluoride content for treating dentin hypersensitivity. Dent Mater (2011) doi:10.1016/j.dental.2011.11.021
Fredholm Y, Karpukhina N, Brauer DS, Jones JR, Law RV, Hill RG. Influence of strontium for calcium substitution in bioactive glasses on degradation, ion release and apatite formation. J R Soc Interface (2011) doi:10.1098/rsif.2011.0387
O’Donnell MD, Karpukhina N, Calver AI, Law RV, Bubb N, Stamboulis A, Hill RG. Real time neutron diffraction and solid state NMR of high strength apatite-mullite glass ceramic. J Non-Cryst Solids (2010) 356:2693-2698
Brauer DS, Karpukhina N, Law RV, Hill RG. Effect of TiO2 addition on structure, solubility and crystallisation of phosphate invert glasses for biomedical applications. J Non-Cryst Solids (2010) 356:2626-2633
Fredholm Y, Karpukhina N, Law RV, Hill RG. Strontium containing bioactive glasses: Glass structure and physical properties. J Non-Cryst Solids (2010) 356:2546-2551
Zainuddin N, Karpukhina N, Hill RG, Law RV. A long-term study on the setting reaction of glass ionomer cements by 27Al MAS-NMR. Dent Mater (2009) 25:290-295
Karpukhina N, Werner-Zwanziger U, Zwanziger JW, Kiprianov AA. Preferntial binding of fluorine to aluminium in high peralkaline aluminosilicate glasses. J Phys Chem B (2007) 111:10413-10420
Nafe H, Karpukhina N. Na-modified cubic zirconia – link between sodium zirconate and zirconia in the Na2O-ZrO2 phase diagram. J Am Ceram Soc (2007) 90:1597-1602
Kiprianov AA, Karpukhina N. Oxyhalide silicate glasses. Glass Phys Chem (2006) 32:1-27
Research interests:
I am working in area of biomedical materials. I use solid-state nuclear magnetic resonance (NMR) spectroscopy to investigate structure of various glasses, cements and apatites. Solid-state NMR is extremely powerful technique to study structure of solids in particular, amorphous solids, and equally informative for crystalline solids. We study structure of bioactive silicate and phosphate glasses containing halogen and other components. We also investigate the setting reactions in various dental and bone cements including glass ionomer cements, calcium, magnesium and zinc phosphate cements using solid-state NMR. We study structure and properties of dental glass ceramics and various substitutions in apatites. Using solid-state NMR in combination with other techniques we also study structure of teeth, bones and other natural apatites. We apply our knowledge on structure of various biomaterials for designing materials for specific biomedical applications. I supervise PhD students and MSc research projects.