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Institute of Dentistry

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Dr Simon Rawlinson, BSc (Hons), PhD

Senior Lecturer in Oral Biology

Email: s.c.f.rawlinson@qmul.ac.uk
Telephone: +44 20 7882 7139
Room Number: Blizard Building

Profile

Research Technician: Bone Unit, The Royal Veterinary College 1986-2000, during this period the group was at the forefront of loadable bone organ culture model development and use. These had the advantage of maintaining the correct ratio of osteoblasts to osteocytes attached to their natural substrate in appropriate 3D orientation. 1999 PhD Veterinary Anatomy, 'Early loading-related responses of resident cells in mammalian bone organ explants'. In the mid-90s loadable cell culture models allowed for the study of cell monocultures to be investigated. At this time I became interested in the apparent disparity of bone mass and mechanical usage of the skull and limb. Research Associate: Bone Unit, The Royal Veterinary College 2000-2003.

Research Associate: Queen Mary University of London, Barts & The London School of Medicine and Dentistry, Institute of Dentistry 2003-2009. In collaboration with staff at the IOD, we investigated the mechanical responsiveness of the mandible and compared the gene profiles of the skull, limb and mandible. This has led us to consider the mechanism by which bone mass is normally maintained at status quo levels. Lecturer: Queen Mary University of London, Barts & The London School of Medicine and Dentistry, Institute of Dentistry 2009 to present. I teach on the 1st Year BDS course and I am the subject convenor for the Respiratory, Cardiovascular and Renal module, a module co-convenor for the MSc Oral Biology course and teach on the MSc Experimental Oral Pathology and intercalated BSc Oral Biology courses.

Research

Research Interests:

The majority of my research has concentrated on the response of limb bone cells in situ to applied, physiological, dynamic mechanical loads with the objective of gaining an insight to the mechanotransduction consequences to usage. The focus changed to investigate how bone mass is preserved in the skull where mechanical loads are low (so low that they would initiate a disuse osteoporosis in the limb). Subsequently, interest has shifted to identify inherent differences between positionally distinct limb and skull bone, and the underlying reasons for any such differences. The locally encoded positional identity is thought ensure like-for-like repair. Mandibular bone has become a site of interest as it seems to possess both limb and skull like properties to the consequences to mechanical loading.

The role of tissue engineering as a means to repair the body has recognised potential for improving patient well-being. I also have interests in the growth and behaviour of bone forming osteoblasts seeded onto different man-made substrates. Identifying the optimal substrate and appropriate source of bone cells will assist in preventing age-related osteoporotic bone fracture and encourage more rapid repair processes in other fractures.

Selected Publications:

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