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Dr Pete Tomlins, BSc (Hons), PhD, CPhys, MInstP

Senior Lecturer in Dental Biometrics (non-clinical)

email: p.h.tomlins@qmul.ac.uk

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Pete Tomlins

Dr Tomlins is an academic member of staff within the Centre for Diagnostic and Oral Sciences.  He completed his undergraduate study at Lancaster University, obtaining a first class BSc (Hons) degree in Physics with Computational Physics. He joined the UK's National Physical Laboratory (NPL) as a Research Scientist in 2002 and worked in the field of fibre optic telecoms.  At NPL, he developed an interest in understanding the physics of biological material and studied part-time with Cranfield University for his PhD in Biomedical Optics.  In 2006 he was appointed as an NPL Senior Research Scientist and over the period 2007 - 2010 he led the Biophotonics group there as Lead Scientist and Technical Area Leader.  In 2009 Pete was appointed as an Honorary Senior Lecturer in Dental Biomaterials within the Dental School at Birmingham University and in August 2010 he took up his current post of Senior Lecturer at Barts and The London Dental School.

Dr Tomlins regularly presents his research at national and international meetings.  He is also a Chartered Physicist of the Institute of Physics (IoP) and member of the IoP Optical Group committee.

Teaching

Research

Research interests:

ptomlins graphic

Dr Tomlins' research interest is in translation of new technology into clinical practice, concentrating specifically on developing quantitative methods for the objective assessment of human tissue (biometrics). He is particularly interested in understanding the interaction of light with human tissue and determining the diagnostic value of different optical parameters through the quantitative and statistical analysis of Optical Coherence Tomography (OCT).  This has led to the development of a technique called Scattering Attenuation Microscopy (SAM) for the early detection of Oral Cancer, with Professor Farida Fortune, Dr Eleni Hagi-Pavli and Dr Oluyori Adegun. The main areas of my research are summarised below:

Tissue Refractive Index

The refractive index of a material carries information about its composition.  The intrinsic ability of OCT to measure optical path-lengths lends it to the measurement of tissue refractive index, the spatial, temporal and inter-sample properties of which are of particular interest.  This is important both from the perspective of fundamental tissue optics, in vivo tissue characterisation and understanding the optical manifestation of disease.

Monte Carlo Modelling of Optical Propagation in Tissue

The optical scattering properties of human tissue are important for understanding optical diagnostic techniques.  Pete uses Monte Carlo computer simulations of light transport to help quantitatively understand OCT tissue measurements and relate the detected signal pattern to underlying disease processes and biology.

Optical Tissue Phantoms

Tissue phantoms are laboratory produced artefacts, having well controlled optical properties that are designed to mimic specific characteristics of biological tissues and calibrate optical diagnostic instruments.  Pete designs, makes and uses these phantoms in his OCT based research.

Selected publications:

  • null (2013) Quantitative optical coherence tomography of fluid-filled oral mucosal lesions. Lasers in Medical Science. vol.28 (5) Article N/A pp.1249-1255
  • null (2010) Scattering attenuation microscopy of oral epithelial dysplasia. Journal of Biomedical Optics. vol.15 (6) Article 066003

View all publications

Key Publications

O.K. Adegun, P.H. Tomlins, et al., Quantitative optical coherence tomography of fluid-filled oral mucosal lesions, Lasers in Medical Science,  28(5), pp. 1249-1255 (2013)

Oluyori Kutulola Adegun, Pete H. Tomlins, Eleni Hagi-Pavli, Gordon Mckenzie, Kim Piper, Dan L. Bader and Farida Fortune. Quantitative analysis of optical coherence tomography and histopathology images of normal and dysplastic oral mucosal tissues. Lasers in Medical Science DOI: 10.1007/s10103-011-0975-1  Online First™, 18 August 2011

Peter H Tomlins, Graham N Smith, Peter D Woolliams, Janarthanan Rasakanthan and Kate Sugden, "Femtosecond Laser Micro-Inscription of Optical Coherence Tomography Resolution Test Artefacts", Biomed. Opt. Expess, 2, pp. 1319-1327, 2011

Peter D Woollaims and Peter H Tomlins, "Estimating the resolution of a commercial optical coherence tomography system with limited spatial sampling", Meas. Sci. Technol., 22, pp. 065502, 2011

Peter D Woolliams and Peter H Tomlins, "Modulation transfer function of an optical coherence tomography imaging system in turbid media", Phys. Med. Biol., 56, pp. 2855-2871, 2011

Jana Rasakanthan, Peter H Tomlins and Kate Sugden, "Processing and Rendering of Fourier Domain Optical Coherence Tomography Images at a Line Rate over 524kHz using a Graphics Processing Unit", J. Biomed. Opt., 16, 2011

Peter H Tomlins, Oluyori Adegun, Eleni Hagi-Pavli, Kim Piper, Dan Bader and Farida Fortune, "Scattering Attenuation Microscopy of Oral Epithelial Dysplasia", J. Biomed. Opt., 15, 066003, 2010

Alex Grimwood, Leo Garcia, Jeff Bamber, Jon Holmes, Peter Woolliams, Peter H Tomlins and Quentin Pankhurst, "Elastographic Contrast Generation in Optical Coherence Tomography from a Localized Shear Stress", Phys. Med. Biol, 55, pp. 5515-5528, 2010

Mohammed A Hadis, Peter H Tomlins, Adrian C Shortall and Will M Palin, "Dynamic monitoring of refractive index change through photoactive resins", Dental Materials, 26, pp. 1106-1112, 2010

Peter D Woolliams and Peter H Tomlins "Spatially Deconvolved Optical Coherence tomography", Appl. Opt., 49, pp. 2014-2021,  2010

Peter H. Tomlins, Peter Woolliams, Christian Hart, Andrew Beaumont, and Matthew Tedaldi, "Optical coherence refractometry", Opt. Lett., 33, pp. 2272-2274, 2008

Peter H. Tomlins and Ruikang K. Wang "Digital Phase Stabilization to Improve Detection Sensitivity for Optical Coherence Tomography", Meas. Sci. Technol., 18, pp. 3365-3372, 2007

Peter H. Tomlins, Will M. Palin, Adrian C. Shortall and Ruikang K. Wang "Time-Resolved Simultaneous Measurement of Group Index and Physical Thickness during Photopolymerization of Resin-Based Dental Composite", J. Biomed. Opt., 12, pp. 014020, 2007

Peter H. Tomlins and Ruikang K. Wang "Simultaneous analysis of refractive index and physical thickness by Fourier domain optical coherence tomography", IEE Proc. Opto., 153, pp. 222-228, 2006

Peter H. Tomlins and Ruikang K. Wang, "Matrix Approach to Quantitative Refractive Index Measurement by Fourier Domain Optical Coherence Tomography", J. Opt. Soc. Am. A, 23, pp. 1897-1907, 2006

Peter H. Tomlins and Ruikang K. Wang, "Theory, Developments and Applications of Optical Coherence Tomography", J. Phys. D: Appl. Phys., 38, pp. 2519-2535, 2005.

Conference Papers and Presentations

A. ADEN*, G. BURNETT, and P. TOMLINS, Using OCT to Investigate Topographical Changes of Enamel During Erosion., British Society of Oral and Dental Research Meeting, Bath, 2013

N. Khan, P. Anderson, S. Rawlinson, P. Tomlins, Identification of Carious Lesions Using Optical Coherence Tomography, ORCA, Liverpool, 2013 (Abstract published in Caries Res 2013;47:433–531)

M.G. Sandrian, P.H. Tomlins, P.D.W. Woolliams, Three-dimensional calibration targets for optical coherence tomography, Proceedings of SPIE   Vol. 8229, pp. 822914 (2012)

Janarthanan Rasakanthan, Peter H Tomlins and Kate Sugden, "Quantitative Optical Coherence Tomography for Characterization of Microscopic Structures with Varying Refractive Index", CLEO Europe 2011

ADEGUN OK , TOMLINS P,  HAGI-PAVLI E,  MCKENZIE G , PIPER K , BADER DL , FORTUNE F, QUANTITATIVE DIFFERENTIATION OF NORMAL AND DYSPLASTIC HUMAN ORAL MUCOSA USING OPTICAL COHERENCE TOMOGRAPHY LASERS MED SCI (2009) 24:825–837

O.K. ADEGUN, P. TOMLINS, G. MCKENZIE, K.M. PIPER, E. HAGI-PAVLI, D.L. BADER, and F. FORTUNE, A POTENTIAL DIAGNOSTIC TOOL FOR THE ORAL MUCOSA BRITISH SOCIETY FOR DENTAL RESEARCH SCIENTIFIC MEETING, GLASGOW, SCOTLAND 1-4 SEPTEMBER 2009 IADR CONFEX

Osayuki Nehikhare, Iakovos Amygdalos, Peter H Tomlins, Marjorie Walker, Josephine Lloyd, Justin Vale and George Hanna, "The optical properties of healthy versus cancerous urological tissue", Society of Academic and Research Surgery, BAUS Academic Urology Meeting, Dublin, 2011

Peter D Woolliams and Peter H Tomlins, "Contrast Phantoms for Optical Coherence Tomography", Proc. SPIE, 7567, 2010

Andrew Beaumont, Michael Hu and Peter H Tomlins, "Understanding the Nature of Optical Coherence Tomography", Proc. SPIE 7566, 2010

Oluyori Adegun, Peter H Tomlins, Gordon McKenzie, Kim Piper, Dan Bader and Farida Fortune "A Potential Diagnostic Tool for the Oral Mucosa", BSDR 2009

Mohammed Hadis, Adrian C Shortall, Peter H Tomlins and William M Palin, "Real Time Optical And Physical Curing Characteristics of Dental Resins", BSDR 2009

Oluyori Adegun, Peter H Tomlins, Gordon McKenzie, Kim Piper, Dan Bader and Farida Fortune, "Optical Coherence Tomography as Potential Monitoring Tool for Oral Lichen Planus", Proc. of SPIE (European Conference on Biomedical Optics), 2009

Oluyori Adegun, Peter H Tomlins, Gordon McKenzie, Kim Piper, Dan Bader and Farida Fortune, "Quantitative Differentiation of Normal and Dysplastic Human Oral Mucosa Using Optical Coherence Tomography", Presented at the British Medical Laser Association Annual Meeting, 2009

Matthew Tedaldi, Peter Woolliams, Christian Hart, Andrew Beaumont and Peter H Tomlins, "Measurement of the refractive index of tissue", Presented at the British Medical Laser Association Annual Meeting, 2009

Peter D Woolliams, Christian Hart, Alex Grimwood and Peter H Tomlins, "Development of test artefacts for optical coherence tomography", Presented at the British Medical Laser Association Annual Meeting, 2009

Matthew Tedaldi, Peter D Woolliams and Peter H Tomlins, "Refractive index mapping of layered samples using multi-angle OCT", Proc. SPIE 7171, 2009

Peter D Woolliams, Alex Grimwood, Christian Hart and Peter H Tomlins, "Development of a 3D resolution test phantom for OCT system validation ", Proc. SPIE, 2009

Peter H. Tomlins, Peter Woolliams, Andrew Beaumont, Christian Hart and Matthew Tedaldi, "Spatial refractive index estimation using multiangle OCT", Proc. SPIE, 2009

William M Palin, Peter H Tomlins, and Adrian C Shortall, "Dynamic monitoring of optical properties during photopolymerization of dental resins", IADR 2008

Peter H Tomlins, William M Palin and Adrian C Shortall, "Dynamic Cure Measurement of Dental Polymer Composites Using Optical Coherence Tomography", Proc. SPIE 6843, pp. 68430D, 2008

Peter H. Tomlins, Peter Woolliams, Matthew Tedaldi, Andrew Beaumont, and Christian Hart, "Three-Dimensional Point-Spread Function Measurement of an Optical Coherence Tomography Imaging System", Proc. SPIE 6847, pp. 68472Q, 2008

Peter H. Tomlins, Yiwei Wang, Bufa Zhang, Matthew Tedaldi, and Paul E. Tomlins, "Complex flow characterisation of a porous tissue scaffold measured by Doppler optical coherence tomography", Proc. SPIE, 6858, 685804 (2008)

Peter H. Tomlins, Matthew Tedaldi, Robert A. Ferguson and Ruikang K. Wang, "Stereoscopic Optical Coherence Tomography in the Frequency Domain for Refractive Index Sensitive Imaging", Proc. of SPIE (European Conference on Biomedical Optics), 6627, pp. 0O1-0O8, 2007

Peter H. Tomlins, Matthew Tedaldi, Robert A. Ferguson and Ruikang K. Wang, "Stereoscopic Optical Coherence Tomography", Presented at the British Medical Laser Association Annual Meeting, 2007

Ruikang K.Wang, S. Cheung, Peter H. Tomlins, C. Chong, A. Morosawa and David Heard, "High-speed frequency-swept light source at 1550 nm for Fourier domain OCT with A-scanning rate at 20 kHz", Proc. SPIE, 6079, 2006

Peter H. Tomlins and Ruikang K. Wang, "Layer Dependent Refractive Index Measurement by Fourier Domain Optical Coherence Tomography", Proc. SPIE, 6079, pp. 6079-32, 2006

Peter H. Tomlins and Ruikang K. Wang, "The Potential of Optical Coherence Tomography for Geometric Analysis and Refractive Index Measurement of Three Dimensional Structures", Presented at the 7th OFMC2005, pp. 129-133, 2005

Patents

P. Tomlins, O.K. Adegun, F. Fortune, Method for identifying dysplastic region of interest in sample e.g. tissue from human or animal body, to treat oral epithelial dysplasia, involves determining region of interest in sample from attenuation depth, Patent Number: WO2012059723-A1; GB2485345-A

PhD Supervision

Public engagement

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