Dr Graham Davis, BSc(Eng), PhD
Reader in 3D X-ray Imaging
Tel: +44 20 7882 5967
Dr Davis graduated as an electronic engineer in 1980 and obtained a PhD in medical electronics in 1984. After working originally in the design of computerised electromyography apparatus, he moved to the London Hospital Medical College (now part of Queen Mary University of London) in 1988 and shortly thereafter began work on the development of X-ray microtomography (XMT). Designing scanners and software algorithms with accuracies exceeding commercially available systems, he is well recognised in this area of development and has served on the European Standards Committee CEN/TC 138/WG 1/AH 1 Computed Tomography. He also serves as a program committee member for the "Developments in X-ray Tomography" conference held every 2 years as part of The International Society for Optical Engineering's (SPIE) International Symposium on Optical Science, Engineering, and Instrumentation. Now a Reader in 3D X-ray Imaging, with many international collaborators using his 3D imaging resource, he is still working on the never-ending quest to improve mineral concentration mapping accuracy in biological hard tissue.
My main research interest is the design and application of advanced X-ray microtomography (XMT or micro-CT) systems. Unlike commercially available systems, these are optimised to produce high quality images giving an accurate representation of the mineral content in biological hard tissue. In dentistry for example, these can be used to precisely map and quantify mineral loss and gain in demineralisation and remineralisation respectively. The high contrast ratio available from these scanners allows us to study small differences in the degree of mineralisation throughout dentine and enamel. The unique availability of these instruments provides opportunities for clinical staff and research students to be involved in cutting edge research in these areas.
The use of this facility also spans many other disciplines including archaeology, palaeontology, petrology and materials science. In fact, current EPSRC funding to design and build the next generation of scanning is for a project aimed at reading historical scrolls which are damaged to the point where they cannot be physically opened. A fascinating project in itself, the technological benefits derived from this will further enhance our on-going dental research.
- null (2013) Mapping the spatial and temporal progression of human dental enamel biomineralization using synchrotron X-ray diffraction. Arch Oral Biol. vol.58 (11) pp.1726-1734
- null (2012) An X-ray Microtomographic Study of Natural White-spot Enamel Lesions. JOURNAL OF DENTAL RESEARCH. vol.91 (2) pp.185-191
- null (2012) X-ray microtomography study to validate the efficacies of caries removal in primary molars by hand excavation and chemo-mechanical technique. Caries Res. vol.46 (6) pp.561-567
- null (2010) Changes in bone mineral and matrix in response to a soft diet. J Dent Res. vol.89 (5) pp.510-514
- null (2009) 3D crystal size distributions: A case study on quantifying olivine populations in kimberlites. vol.112 pp.223-235
Karunaratne, A., Davis, G. R.,Hiller, J.,Esapa, C. T.,Terrill, N. J.,Brown, S. D.,Cox, R. D.,Thakker, R. V.,Gupta, H. S. Hypophosphatemic rickets is associated with disruption of mineral orientation at the nanoscale in the flat scapula bones of rachitic mice with development. BONE (in press)
Davis, G.R., Tayab, R.A., Seymore K.G., Cherukara G.P. (2012, July). Quantification of residual dentine thickness following crown preparation. JOURNAL OF DENTISTRY, 40(7), 571-6.
Cochrane, N. J., Anderson, P., Davis, G. R., Adams, G. G., Stacey, M. A., & Reynolds, E. C. (2012, February). An X-ray Microtomographic Study of Natural White-spot Enamel Lesions. JOURNAL OF DENTAL RESEARCH, 91, 185-191. doi:10.1177/0022034511429570
Tarplee, M. F. V., van der Meer, J. J. M., & Davis, G. R. (2011, November). The 3D microscopic 'signature' of strain within glacial sediments revealed using X-ray computed microtomography. QUATERNARY SCIENCE REVIEWS, 30, 3501-3532. doi:10.1016/j.quascirev.2011.05.016
Jerram, D. A., Mock, A., Davis, G. R., Field, M., & Brown, R. J. (2009, November). 3D crystal size distributions: A case study on quantifying olivine populations
in kimberlites. Lithos, 112S1, 223-235.
Davis, G., Evershed, A., Elliott, J., & Mills, D. (2010). Quantitative X-ray microtomography with a conventional source. In S. R. Stock (Ed.), DEVELOPMENTS IN X-RAY TOMOGRAPHY VII Vol. 7804 (pp. ). doi:10.1117/12.861355
Jerram, D. A., Davis, G. R., Mock, A., Charrier, A., & Marsh, B. D. (2010, October). Quantifying 3D crystal populations, packing and layering in shallow intrusions: A case study from the Basement Sill, Dry Valleys, Antarctica. GEOSPHERE, 6(5), 537-548. doi:10.1130/GES00538.1
Kingsmill, V. J., Boyde, A., Davis, G. R., Howell, P. G., & Rawlinson, S. C. (2010, May). Changes in bone mineral and matrix in response to a soft diet.. J Dent Res, 89(5), 510-514. doi:10.1177/0022034510362970
Brook, A. H., Griffin, R. C., Smith, R. N., Townsend, G. C., Kaur, G., Davis, G. R., . . . Fearne, J. (2009, December). Tooth size patterns in patients with hypodontia and supernumerary teeth. In ARCHIVES OF ORAL BIOLOGY Vol. 54 (pp. S63-S70). doi:10.1016/j.archoralbio.2008.05.016
Jerram, D. A., Mock, A., Davis, G. R., Field, M., & Brown, R. J. (2009, November). 3D crystal size distributions: A case study on quantifying olivine populations in kimberlites. In LITHOS Vol. 112 (pp. 223-235). doi:10.1016/j.lithos.2009.05.042
Rawlinson, S. C., Boyde, A., Davis, G. R., Howell, P. G., Hughes, F. J., & Kingsmill, V. J. (2009, July). Ovariectomy vs. hypofunction: their effects on rat mandibular bone.. J Dent Res, 88(7), 615-620. doi:10.1177/0022034509340132
Kawabata, M., Hector, M. P., Davis, G. R., Parkinson, C. R., Rees, G. D., & Anderson, P. (2008, August). Diffusive transport within dentinal tubules: an X-ray microtomographic study.. Arch Oral Biol, 53(8), 736-743. doi:10.1016/j.archoralbio.2008.03.012
Elliott, J. C., Davis, G. R., & Dover, S. D. (2008). X-ray microtomography, past and present - art. no. 707803. In S. R. Stock (Ed.), DEVELOPMENTS IN X-RAY TOMOGRAPHY VI Vol. 7078 (pp. 7803).
Davis, G., Jain, N., & Elliott, J. (2008). A modelling approach to beam hardening correction - art. no. 70781E. In S. R. Stock (Ed.), DEVELOPMENTS IN X-RAY TOMOGRAPHY VI Vol. 7078 (pp. E781).