Dr Eleni Hagi-Pavli, BSc (Hons), PhD
Lecturer in Oral Sciences
Tel: +44 20 7882 7141
Dr Eleni Hagi-Pavli completed her undergraduate study at the University of Birmingham with a BSc (Hons) in Chemistry and a PhD from Barts and the Royal London Medical and Dental School in 1996 from the Department of Chemical Pathology. Her thesis title was ‘Designing immunogens for the generation of antibodies that catalyse the hydrolysis of cocaine’ where she was searching for an antidote for cocaine poisoning in the field of catalytic antibodies.. Her post-doctoral training is exclusively in the field of Dentistry where she has been able to develop her research expertise and interest in the area of mucosal biology. Dr Hagi-Pavli has investigated the oral mucosa’s response to different stimuli by studying the signaling mechanisms by which adhesion molecules and cytokines are induced by vasoactive peptides as well as the oral mucosa’s response to small organic and inorganic molecules found in oral healthcare products. She has worked with Professor David Williams and Dr Alan Cruchley on collaborative studies with Unilever and more recently and prior to her appointment as lecturer with GlaxoSmithKline. During her post-doctoral studies she has won Travel Fellowships from the Wellcome Trust and the Endocrinology Society to visit the University of Pennsylvania Dental School where she researched the role of vascular endothelial growth factor (VEGF) in oral homeostasis and where her interest in salivary growth factors began and still continues. She has recently been appointed to the position of ‘Non-clinical lecturer in Oral Sciences’.
Dr Hagi-Pavli’s research interests include looking at the differences that can be found between salivary growth factors such as vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) in patients with inflammatory mucosal disease in particular patients with Behcet’s disease who exhibit delayed oral ulcer healing. Dr Hagi-Pavli has presented this work both nationally and internationally. She is also involved in profiling the saliva of patients with differing inflammatory mucosal disease so that one may be able to have at hand a non-invasive and relatively inexpensive method by which patients may be screened at the same time for Behcet’s, Crohns, Sjogrens and other chronic diseases and therefore more easily diagnosed. In collaboration with Professor Farida Fortune she has become involved research which includes basic biology and clinical oral research in investigating mucosal inflammation following underlying chronic disease situations such as Behcet’s, Crohns Disease, Lichen planus and Erytheme Multiforme. The aim of this work is to understand how acute inflammation is opposed and homeostasis restored in chronic disease. More recently she has been involved in the development of a technique called Scattering Attenuation Microscopy (SAM) with Professor Farida Fortune, Dr Pete Tomlins and Dr Oluyori Adegun that will be used for the early detection of oral cancer.
Dr Hagi-Pavli’s research is positioned within the Infection, Immunity and Inflammation and Oral cancer research groups.
Dr Hagi-Pavli received her Certificate in Learning and Teaching (CILT) in Medical and Dental Education in 2008 and has been nominated for a Drapers’ Award for Excellence in Teaching. She co-ordinates and teaches on the postgraduate Diploma in Dental Clinical Sciences for internationally qualified dentists but also teaches and supervises research projects on the MSc in Experimental Oral Pathology (Oral Sciences). She currently supervises three PhD students.
- null (2012) Candida albicans strain-dependent modulation of pro-inflammatory cytokine release by in vitro oral and vaginal mucosal models. Cytokine. vol.57 (1) pp.89-97
- null (2011) Age, gender and disease-related platelet and neutrophil activation ex vivo in whole blood samples from patients with Behçet's disease. Rheumatology (Oxford). vol.50 (10) pp.1849-1859
- null (2009) Oral health and related quality of life status in patients from UK and Turkey: a comparative study in Behcet's disease. J ORAL PATHOL MED. vol.38 (5) pp.406-409
Peter H Tomlins, Oluyori Adegun, Eleni Hagi-Pavli, Kim Piper, Dan Bader and Farida Fortune, "Scattering Attenuation Microscopy of Oral Epithelial Dysplasia", J. Biomed. Opt., 15, 066003, 2010
Mumcu G, Niazi S, Stewart J, Hagi-Pavli E, Gokani B, Seoudi N, et al. Oral health and related quality of life status in patients from UK and Turkey: a comparative study in Behcet's disease. J Oral Pathol Med. 2009.
Tilakaratne WM, Iqbal Z, Teh MT, Ariyawardana A, Pitiyage G, Cruchley A, Stewart JE, Hagi-Pavli E, Lalli A, Waseem A, Parkinson EK, Fortune F. Upregulation of HIF-1alpha in malignant transformation of oral submucous fibrosis. J Oral Pathol Med. 2008 Jul;37(6):372-7. 18221327.
Teh MT, Tilakaratne WM, Chaplin T, Young BD, Ariyawardana A, Pitiyage G, Lalli A, Stewart JE, Hagi-Pavli E, Cruchley A, Waseem A, Fortune F. Fingerprinting genomic instability in oral submucous fibrosis. J Oral Pathol Med. 2008 Aug;37(7):430-6. Epub 2008 Feb 17.
Lalli A, Tilakaratne WM, Ariyawardana A, Fitchett C, Leigh IM, Hagi-Pavli E, et al. An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity. J Oral Pathol Med. 2008; 37(4): 211-20.
Hagi-Pavli, E., Farthing, P. M., Henshaw, F. N., And Kapas, S. (2005) Presentation of ICAM-1 protein at the cell surface of oral keratinocytes in the presence of adrenomedullin and corticotrophin. Cell Physiol Biochem 15, 167-174
Hagi-Pavli, E., Farthing, P. M., And Kapas, S. (2004) Stimulation of adhesion
molecule expression in human endothelial cells (HUVEC) by adrenomedullin
and corticotrophin. Am J Physiol Cell Physiol 286, C239-246
Pleguezuelos, O., Hagi-Pavli, E., Crowther, G., And Kapas, S. (2004).
Adrenomedullin signals through NF-kappaB in epithelial cells. FEBS Lett 577, 249-254
Kapas, S., Pahal, K., Cruchley, A. T., Hagi-Pavli, E., And Hinson, J. P (2004).
Expression of adrenomedullin and its receptors in human salivary tissue. J Dent Res 83, 333-337
Selvaratnam L, Cruchley AT, Hagi-Pavli E, Wertz P, Navsaria H, Leigh IM, Squier CA and Williams DM. (2001).
Oral Keratinocytes Develop a Functional and Biochemical Permeability Barrier Similar to Intact Oral Mucosa. Oral Diseases 7(4) 252-8.
S. Kapas, A. Bansal, V. Bhargava, R. Maher, D. Malli, E. Hagi-Pavli & R. P. Allaker. (2001). Adrenomedullin expression in pathogen supernatant-challenged oral epithelial cells. Peptides. 22. 1485-1489.
Hagi-Pavli EP, Simms CS, Ostler EL, Brocklehurst K and Gallacher G (1999).
Synthesis of a transition state analogue for the hydrolysis of cocaine: assistance to phosphonylation of a 3beta-hydroxytropane by a neighbouring amide group. Bioorganic & Medicinal Chemistry Letters. 9 (13): 1881-4.
Taichman NS, Cruchley AT, Fletcher LM, Hagi-Pavli EP, Paleolog EM, Abrams WR, Booth V, Edwards RM, Malamud D. (1998). Vascular endothelial growth factor in normal human salivary glands and saliva: a possible role in the maintenance of mucosal homeostasis. Laboratory Investigation. 78 (7): 869-75.
Kapas S, Brown DW, Farthing PM, Hagi-Pavli E. (1997).
Adrenomedullin has mitogenic effects on human oral keratinocytes: involvement of cyclic AMP. FEBS Letters. 418 (3): 287-90.
Hagi-Pavli, E, Brown D, Farthing PM, Kapas, S. (1997).
Effects of peptide growth factors on cAMP levels and cellular adhesion factors in human keratinocyte cell lines.
FASEB J 11(3): 14-15