Dr Paul Anderson

Qualifications: BSc, PhD
Position: Reader in Biophysics in relation to Dentistry
Associated Centre/s: Oral Growth and Development

2002-present  Reader in Biophysics in Relation to Dentistry
Centre for Oral Growth and Development
Queen Mary's School of Medicine and Dentistry
Queen Mary, University of London

1997-2002   Senior Lecturer, Dept. of Oral Growth and Development.
Queen Mary's School of Medicine and Dentistry
Queen Mary, University of London

1996-1997  Lecturer,
Dept. of Biophysics in relation to Dentistry
Queen Mary and Westfield College (now QMUL)

1993-1996 Lecturer,
Dept. of Child Dental Health,  London Hospital Medical College

1987-1993 Research Assistant,
Dept. of Child Dental Health, London Hospital Medical College

1987 May-Aug Visiting Scientist,
Dept. of Chemistry, The University of Western Ontario, Ontario, Canada

1987 Jan-Apr  Software Engineer,
Dept. of Instrumentation and Applied Physics
UK Atomic Energy Research Establishment (now AEA Technologies plc)  Harwell, UK.

1983-1987 Research Assistant
Dept. of Biochemistry, London Hospital Medical College

 

Research

My main research area is the chemistry of enamel and hydroxyapatite in the context of de and remineralisation of enamel. Recently, I have developed research into the influence of salivary proteins on these processes, to study their role in enamel homeostasis. I have developed novel X-ray absorption microscopies to assist with these studies, and have also used these technologies to study diffusion processes in enamel, and the efficacy of treatments for dental hypersensitivity. I have been sponsored by the MRC, EPSRC, Wellcome, as well as RAB, and QMUL grants. I currently have several PhD students, and a Postdoctoral research assistant.

Publications

Key Publications

Anderson P, Elliott JC. Scanning X-ray microradiographic study of the formation of caries-like lesions in synthetic apatite aggregates. Caries Res. 19:403-406 (1985).

Anderson P, Elliott JC. Coupled diffusion as basis for subsurface demineralization in dental caries. Caries Res. 21: 522-525 (1987).

Anderson P, Elliott JC. Subsurface demineralisation in dental enamel and other permeable solids during acid dissolution.  J Dent Res 71 1473-1481 (1992).

Anderson P, Dowker SEP, Elliott JC, Thomas CR. Synchrotron X-ray fluorescence microprobe analysis in the study of dental mineralized tissues. J. Trace and Microprobe Techniques 14:541-560 (1996).

Anderson P, Levinkind M, Elliott JC. Scanning microradiographic studies of rates of in vitro demineralisation in human and bovine dental enamel.  Archs oral Biol (1998) 43;649-656.

Anderson P, Elliott JC.  Rates of mineral loss in human enamel during in vitro demineralization perpendicular and parallel to the natural surface.  Caries Res (2000) 34:33-40.

Anderson P, Hector MP, Rampersad MA. Critical pH in resting and stimulated whole saliva in a group of children. Int. J. Paediatric Dentistry  (2001) 11:266-273.

Anderson P, Bollet-Quivogne FR, Dowker SEP, Elliott JC. Demineralization in enamel and Hydroxyapatite aggregates at increasing ionic strength. Archs Oral Biol  (2004):49;199-207.
Anderson P, Ahmed Y, Patel MP, Davis GR, Braden M.X-ray microtomographic studies of novel radio-opaque polymeric materials for dental applications. Mat. Sci. Tech (2006);22(9),1094-1097.

Kosoric J, Williams RAD, Hector MP, Anderson P. A synthetic peptide based on a natural salivary protein reduces demineralization in model systems for dental caries and erosion. J. Peptide Res and Therapeutics  (Published on-line   DOI: 10.1007/s10989-007-9085-0)

 


PubLists Publications

Cochrane NJ, Anderson P, Davis GR et al. (2012). An X-ray Microtomographic Study of Natural White-spot Enamel Lesions JOURNAL OF DENTAL RESEARCH 91, (2) 0022-0345 185-191.
10.1177/0022034511429570

Shah S, Kosoric J, Hector MP et al. (2011). An in vitro scanning microradiography study of the reduction in hydroxyapatite demineralization rate by statherin-like peptides as a function of increasing N-terminal length. Eur J Oral Sci 119 Suppl 1, () 13-18.
10.1111/j.1600-0722.2011.00899.x

Anderson P, Beeley J, Monteiro PM et al. (2011). A European Core Curriculum in Cariology: the knowledge base EUROPEAN JOURNAL OF DENTAL EDUCATION 15, () 1396-5883 18-22.
10.1111/j.1600-0579.2011.00709.x

Kosoric J, Hector MP, Anderson P (2010). The influence of proteins on demineralization kinetics of hydroxyapatite aggregates J BIOMED MATER RES A 94A, (3) 1549-3296 972-977.
10.1002/jbm.a.32759

Mishra S, Thomas HF, Fearne JM et al. (2009). Comparison of demineralisation rates in pre- and postnatal enamel and at the neonatal line. Arch Oral Biol 54 Suppl 1, () S101-S106.
10.1016/j.archoralbio.2008.09.013

Kawabata M, Hector MP, Davis GR et al. (2008). Diffusive transport within dentinal tubules: an X-ray microtomographic study. Arch Oral Biol 53, (8) 0003-9969 736-743.
10.1016/j.archoralbio.2008.03.012

Santos O, Kosoric J, Hector MP et al. (2008). Adsorption behavior of statherin and a statherin peptide onto hydroxyapatite and silica surfaces by in situ ellipsometry J COLLOID INTERF SCI 318, (2) 0021-9797 175-182.
10.1016/j.jcis.2007.11.015

Kosoric J, Williams RAD, Hector MP et al. (2007). A synthetic peptide based on a natural salivary protein reduces demineralisation in model systems for dental caries and erosion INT J PEPT RES THER 13, (4) 1573-3149 497-503.
10.1007/s10989-007-9085-0

Bollet-Quivogne FRG, Anderson P, Dowker SEP et al. (2007). Demineralisation of permeable hydroxyapatite with alternating water and acidic buffer: Scanning microradiographic study of effect of switching period CARIES RES 41, (2) 0008-6568 152-160.
10.1159/000098050

Anderson P, Ahmed Y, Patel MP et al. (2006). X-ray microtomographic studies of novel radio-opaque polymeric materials for dental applications MATERIALS SCIENCE AND TECHNOLOGY 22, (9) 0267-0836 1094-1097.
10.1179/174328406X114180

Fabes J, Anderson P, Yanez-Munoz RJ et al. (2006). Accumulation of the inhibitory receptor EphA4 may prevent regeneration of corticospinal tract axons following lesion EUR J NEUROSCI 23, (7) 0953-816X 1721-1730.
10.1111/j.1460-9568.2006.04704.x

Potter K, Sweet DE, Anderson P et al. (2006). Non-destructive studies of tissue-engineered phalanges by magnetic resonance microscopy and X-ray microtomography BONE 38, (3) 8756-3282 350-358.
10.1016/j.bone.2005.08.025

Elliott JC, Bollet-Quivogne FRG, Anderson P et al. (2005). Acidic demineralization of apatites studied by scanning X-ray microradiography and microtomography MINERALOGICAL MAGAZINE 69, (5) 0026-461X 643-652.
10.1180/0026461056950276

Moreau P, Raulic M, P'ng KMY et al. (2005). Measurement of the size effect in the yield strength of nickel foils PHIL MAG LETT 85, (7) 0950-0839 339-343.
10.1080/09500830500071564

Bollet-Quivogne FR, Anderson P, Dowker SE et al. (2005). Scanning microradiographic study on the influence of diffusion in the external liquid on the rate of demineralization in hydroxyapatite aggregates. Eur J Oral Sci 113, (1) 0909-8836 53-59.
10.1111/j.1600-0722.2005.00188.x

Wong FS, Anderson P, Fan H et al. (2004). X-ray microtomographic study of mineral concentration distribution in deciduous enamel. Arch Oral Biol 49, (11) 0003-9969 937-944.
10.1016/j.archoralbio.2004.05.011

Li L, Grønning LM, Anderson PO et al. (2004). Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism. J Biol Chem 279, (33) 0021-9258 34107-34114.
10.1074/jbc.M312672200

Washburn NR, Weir M, Anderson P et al. (2004). Bone formation in polymeric scaffolds evaluated by proton magnetic resonance microscopy and X-ray microtomography J BIOMED MATER RES A 69A, (4) 0021-9304 738-747.
10.1002/jbm.a.30054

Fearne J, Anderson P, Davis GR (2004). 3D X-ray microscopic study of the extent of variations in enamel density in first permanent molars with idiopathic enamel hypomineralisation. Br Dent J 196, (10) 0007-0610 634-638.
10.1038/sj.bdj.4811282

Anderson P, Bollet-Quivogne FR, Dowker SE et al. (2004). Demineralization in enamel and hydroxyapatite aggregates at increasing ionic strengths. Arch Oral Biol 49, (3) 0003-9969 199-207.
10.1016/j.archoralbio.2003.10.001

Nalbantoglu ER, Anderson P, Hector MP (2003). Scanning microradiographic study of demineralisation in low porosity hydroxyapatite aggregates. JOURNAL OF DENTAL RESEARCH 82, () 0022-0345 517-517.

Bollet-Quivogne FRG, Anderson P, Dowker SEP et al. (2003). Scanning microradiographic study of mineral redeposition during hydroxyapatite lesion formation. JOURNAL OF DENTAL RESEARCH 82, () 0022-0345 483-483.

Wong FSL, Anderson P, Fan H (2003). X-ray microtomographic measurement of mineral concentrations in deciduous enamel. JOURNAL OF DENTAL RESEARCH 82, () 0022-0345 516-516.

Anderson P, Sundstedt A, Li L et al. (2003). Differential activation of signal transducer and activator of transcription (STAT)3 and STAT5 and induction of suppressors of cytokine signalling in T(h)1 and T(h)2 cells. Int Immunol 15, (11) 0953-8178 1309-1317.
10.1093/intimm/dxg130

Justice I, Derby B, Davis G et al. (2003). Characterisation of void and reinforcement distributions in a metal matrix composite by X-ray edge-contrast microtomography SCRIPTA MATER 48, (9) 1359-6462 1259-1264.
10.1016/S1359-6462(03)00050-2

Mercer CE, Anderson P, Davis GR (2003). Sequential 3D X-ray microtomographic measurement of enamel and dentine ablation by an Er:YAG laser. Br Dent J 194, (2) 0007-0610 99-104.
10.1038/sj.bdj.4809883

ANDERSON P, Dowker SEP, Elliott JC et al. (2003). Scanning Microradiography - a digital 2-D X-ray imaging technique GIT Imaging & Microscopy 5, () 22-24.

Mercer CE, Anderson P, Davis G (2003). Sequential measurement of enamel and dentine ablation by an Er : YAG laser using 3D X-ray microtomography LASERS IN DENTISTRY, PROCEEDINGS 1248, () 0531-5131 131-134.
10.1016/S0531-5131(02)01322-5

Driscoll CO, Dowker SEP, Anderson P et al. (2002). Effects of sodium hypochlorite solution on root dentine composition J MATER SCI-MATER M 13, (2) 0957-4530 219-223.
10.1023/A:1013894432622

ANDERSON P, Dowker SEP, Davis GR et al. (2002). Non-destructive 3D structural studies by X-ray microtomography. Advances in X-ray Analysis 45, () 485-490.

Anderson P, Hector MP, Rampersad MA (2001). Critical pH in resting and stimulated whole saliva in groups of children and adults. Int J Paediatr Dent 11, (4) 0960-7439 266-273.
10.1046/j.1365-263X.2001.00293.x

Groth EB, Mercer CE, Anderson P (2001). Microtomographic analysis of subsurface enamel and dentine following Er:YAG laser and acid etching. Eur J Prosthodont Restor Dent 9, (2) 0965-7452 73-79.

Peariasamy K, Anderson P, Brook AH (2001). A quantitative study of the effect of pumicing and etching on the remineralisation of enamel opacities. Int J Paediatr Dent 11, (3) 0960-7439 193-200.

Contact

Dr Paul Anderson

This email address is being protected from spambots. You need JavaScript enabled to view it.
+44 20 7882 5962 (Tel)
+44 20 7295 7931 (Fax)

Dental Biophysics
Queen Mary, University of London
Mile End Road
London
E1 4NS

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