Dr Graham Davis

Qualifications: BSc(Eng), PhD
Position: Reader in 3D X-ray Imaging
Associated Centre/s: Oral Growth and Development

Dr Davis graduated as an electronic engineer in 1980 and obtained a PhD in medical electronics in 1984.  After working originally in the design of computerised electromyography apparatus, he moved to the London Hospital Medical College (now part of Queen Mary University of London) in 1988 and shortly thereafter began work on the development of X-ray microtomography (XMT).  Designing scanners and software algorithms with accuracies exceeding commercially available systems, he is well recognised in this area of development and has served on the European Standards Committee CEN/TC 138/WG 1/AH 1 Computed Tomography. He also serves as a program committee member for the "Developments in X-ray Tomography" conference held every 2 years as part of The International Society for Optical Engineering's (SPIE) International Symposium on Optical Science, Engineering, and Instrumentation. Now a Reader in 3D X-ray Imaging, with many international collaborators using his 3D imaging resource, he is still working on the never-ending quest to improve mineral concentration mapping accuracy in biological hard tissue.

Research

My main research interest is the design and application of advanced X-ray microtomography (XMT or micro-CT) systems.  Unlike commercially available systems, these are optimised to produce high quality images giving an accurate representation of the mineral content in biological hard tissue.  In dentistry for example, these can be used to precisely map and quantify mineral loss and gain in demineralisation and remineralisation respectively.  The high contrast ratio available from these scanners allows us to study small differences in the degree of mineralisation throughout dentine and enamel.  The unique availability of these instruments provides opportunities for clinical staff and research students to be involved in cutting edge research in these areas.

The use of this facility also spans many other disciplines including archaeology, palaeontology, petrology and materials science.  In fact, current EPSRC funding to design and build the next generation of scanning is for a project aimed at reading historical scrolls which are damaged to the point where they cannot be physically opened.  A fascinating project in itself, the technological benefits derived from this will further enhance our on-going dental research.

Publications

Key Publications

Karunaratne, A., Davis, G. R.,Hiller, J.,Esapa, C. T.,Terrill, N. J.,Brown, S. D.,Cox, R. D.,Thakker, R. V.,Gupta, H. S.  Hypophosphatemic rickets is associated with disruption of mineral orientation at the nanoscale in the flat scapula bones of rachitic mice with development. BONE (in press)
10.1016/j.bone.2012.04.021

Davis, G.R., Tayab, R.A., Seymore K.G., Cherukara G.P. (2012, July). Quantification of residual dentine thickness following crown preparation. JOURNAL OF DENTISTRY, 40(7), 571-6.
doi:10.1016/j.jdent.2012.03.006

Cochrane, N. J., Anderson, P., Davis, G. R., Adams, G. G., Stacey, M. A., & Reynolds, E. C. (2012, February). An X-ray Microtomographic Study of Natural White-spot Enamel Lesions. JOURNAL OF DENTAL RESEARCH, 91, 185-191. doi:10.1177/0022034511429570

Tarplee, M. F. V., van der Meer, J. J. M., & Davis, G. R. (2011, November). The 3D microscopic 'signature' of strain within glacial sediments revealed using X-ray computed microtomography. QUATERNARY SCIENCE REVIEWS, 30, 3501-3532. doi:10.1016/j.quascirev.2011.05.016

Jerram, D. A., Mock, A., Davis, G. R., Field, M., & Brown, R. J. (2009, November). 3D crystal size distributions: A case study on quantifying olivine populations
in kimberlites. Lithos, 112S1, 223-235.

Davis, G., Evershed, A., Elliott, J., & Mills, D. (2010). Quantitative X-ray microtomography with a conventional source. In S. R. Stock (Ed.), DEVELOPMENTS IN X-RAY TOMOGRAPHY VII Vol. 7804 (pp. ). doi:10.1117/12.861355

Jerram, D. A., Davis, G. R., Mock, A., Charrier, A., & Marsh, B. D. (2010, October). Quantifying 3D crystal populations, packing and layering in shallow intrusions: A case study from the Basement Sill, Dry Valleys, Antarctica. GEOSPHERE, 6(5), 537-548. doi:10.1130/GES00538.1

Kingsmill, V. J., Boyde, A., Davis, G. R., Howell, P. G., & Rawlinson, S. C. (2010, May). Changes in bone mineral and matrix in response to a soft diet.. J Dent Res, 89(5), 510-514. doi:10.1177/0022034510362970

Brook, A. H., Griffin, R. C., Smith, R. N., Townsend, G. C., Kaur, G., Davis, G. R., . . . Fearne, J. (2009, December). Tooth size patterns in patients with hypodontia and supernumerary teeth. In ARCHIVES OF ORAL BIOLOGY Vol. 54 (pp. S63-S70). doi:10.1016/j.archoralbio.2008.05.016

Jerram, D. A., Mock, A., Davis, G. R., Field, M., & Brown, R. J. (2009, November). 3D crystal size distributions: A case study on quantifying olivine populations in kimberlites. In LITHOS Vol. 112 (pp. 223-235). doi:10.1016/j.lithos.2009.05.042

Rawlinson, S. C., Boyde, A., Davis, G. R., Howell, P. G., Hughes, F. J., & Kingsmill, V. J. (2009, July). Ovariectomy vs. hypofunction: their effects on rat mandibular bone.. J Dent Res, 88(7), 615-620. doi:10.1177/0022034509340132

Kawabata, M., Hector, M. P., Davis, G. R., Parkinson, C. R., Rees, G. D., & Anderson, P. (2008, August). Diffusive transport within dentinal tubules: an X-ray microtomographic study.. Arch Oral Biol, 53(8), 736-743. doi:10.1016/j.archoralbio.2008.03.012

Elliott, J. C., Davis, G. R., & Dover, S. D. (2008). X-ray microtomography, past and present - art. no. 707803. In S. R. Stock (Ed.), DEVELOPMENTS IN X-RAY TOMOGRAPHY VI Vol. 7078 (pp. 7803).

Davis, G., Jain, N., & Elliott, J. (2008). A modelling approach to beam hardening correction - art. no. 70781E. In S. R. Stock (Ed.), DEVELOPMENTS IN X-RAY TOMOGRAPHY VI Vol. 7078 (pp. E781).


PubLists Publications

Davis GR, Evershed AN, Mills D (2013). Quantitative high contrast X-ray microtomography for dental research. J Dent , () -.
10.1016/j.jdent.2013.01.010

Karunaratne A, Davis GR, Hiller J et al. (2012). Hypophosphatemic rickets is associated with disruption of mineral orientation at the nanoscale in the flat scapula bones of rachitic mice with development. Bone 51, (3) 553-562.
10.1016/j.bone.2012.04.021

Davis GR, Tayeb RA, Seymour KG et al. (2012). Quantification of residual dentine thickness following crown preparation. J Dent 40, (7) 571-576.
10.1016/j.jdent.2012.03.006

Cochrane NJ, Anderson P, Davis GR et al. (2012). An X-ray Microtomographic Study of Natural White-spot Enamel Lesions JOURNAL OF DENTAL RESEARCH 91, (2) 0022-0345 185-191.
10.1177/0022034511429570

Ahmed M, Davis GR, Wong FS (2012). X-ray microtomography study to validate the efficacies of caries removal in primary molars by hand excavation and chemo-mechanical technique. Caries Res 46, (6) 561-567.
10.1159/000341804

Tarplee MFV, van der Meer JJM, Davis GR (2011). The 3D microscopic 'signature' of strain within glacial sediments revealed using X-ray computed microtomography QUATERNARY SCIENCE REVIEWS 30, (23-24) 0277-3791 3501-3532.
10.1016/j.quascirev.2011.05.016

Jerram DA, Davis GR, Mock A et al. (2010). Quantifying 3D crystal populations, packing and layering in shallow intrusions: A case study from the Basement Sill, Dry Valleys, Antarctica GEOSPHERE 6, (5) 1553-040X 537-548.
10.1130/GES00538.1

Kingsmill VJ, Boyde A, Davis GR et al. (2010). Changes in bone mineral and matrix in response to a soft diet. J Dent Res 89, (5) 510-514.
10.1177/0022034510362970

Davis G, Evershed A, Elliott J et al. (2010). Quantitative X-ray microtomography with a conventional source DEVELOPMENTS IN X-RAY TOMOGRAPHY VII 7804, () 0277-786X -.
10.1117/12.861355

Brook AH, Griffin RC, Smith RN et al. (2009). Tooth size patterns in patients with hypodontia and supernumerary teeth ARCHIVES OF ORAL BIOLOGY 54, () 0003-9969 S63-S70.
10.1016/j.archoralbio.2008.05.016

Jerram DA, Mock A, Davis GR et al. (2009). 3D crystal size distributions: A case study on quantifying olivine populations in kimberlites Lithos 112S1, () 223-235.

Jerram DA, Mock A, Davis GR et al. (2009). 3D crystal size distributions: A case study on quantifying olivine populations in kimberlites LITHOS 112, () 0024-4937 223-235.
10.1016/j.lithos.2009.05.042

Rawlinson SC, Boyde A, Davis GR et al. (2009). Ovariectomy vs. hypofunction: their effects on rat mandibular bone. J Dent Res 88, (7) 615-620.
10.1177/0022034509340132

Davis GR, Safir F, Boyde A (2009). X-ray microtomography and scanning electron microscopy in study of loss of articular calcified cartilage and subchondral bone in human femoral head INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY 90, (1) 0959-9673 A72-A72.

Kawabata M, Hector MP, Davis GR et al. (2008). Diffusive transport within dentinal tubules: an X-ray microtomographic study. Arch Oral Biol 53, (8) 0003-9969 736-743.
10.1016/j.archoralbio.2008.03.012

Davis G, Jain N, Elliott J (2008). A modelling approach to beam hardening correction - art. no. 70781E DEVELOPMENTS IN X-RAY TOMOGRAPHY VI 7078, () 0277-786X E781-E781.
10.1117/12.794808

Elliott JC, Davis GR, Dover SD (2008). X-ray microtomography, past and present - art. no. 707803 DEVELOPMENTS IN X-RAY TOMOGRAPHY VI 7078, () 0277-786X 7803-7803.
10.1117/12.793959

Atar M, Davis GR, Verry P et al. (2007). Enamel mineral concentration in diabetic rodents. Eur Arch Paediatr Dent 8, (4) 1818-6300 195-200.

Partap S, Muthutantri A, Rehman IU et al. (2007). Preparation and characterisation of controlled porosity alginate hydrogels made via a simultaneous micelle templating and internal gelation process JOURNAL OF MATERIALS SCIENCE 42, (10) 0022-2461 3502-3507.
10.1007/s10853-007-1533-x

Willmott NS, Wong FSL, Davis GR (2007). An X-ray microtomography study on the mineral concentration of carious dentine removed during cavity preparation in deciduous molars CARIES RES 41, (2) 0008-6568 129-134.
10.1159/000098046

Wong FS, Willmott NS, Davis GR (2006). Dentinal carious lesion in three dimensions. Int J Paediatr Dent 16, (6) 0960-7439 419-423.
10.1111/j.1365-263X.2006.00766.x

Davis GR, Elliott JC (2006). Artefacts in X-ray microtomography of materials MATERIALS SCIENCE AND TECHNOLOGY 22, (9) 0267-0836 1011-1018.
10.1179/174328406X114117

Polly PD, Wesley-Hunt GD, Heinrich RE et al. (2006). Earliest known carnivoran auditory bulla and support for a recent origin of crown-group carnivora (Eutheria, Mammalia) PALAEONTOLOGY 49, () 0031-0239 1019-1027.
10.1111/j.1475-4983.2006.00586.x

Ignatiev KI, Davis GR, Elliott JC et al. (2006). MicroCT (microtomography) quantification of microstructure related to macroscopic behaviour - Part 1 - Fatigue crack closure measured in situ in AA 2090 compact tension samples MATERIALS SCIENCE AND TECHNOLOGY 22, (9) 0267-0836 1025-1037.
10.1179/174328406X114144

Anderson P, Ahmed Y, Patel MP et al. (2006). X-ray microtomographic studies of novel radio-opaque polymeric materials for dental applications MATERIALS SCIENCE AND TECHNOLOGY 22, (9) 0267-0836 1094-1097.
10.1179/174328406X114180

Davis G (2006). X-ray microtomography: what is a voxel? J ANAT 209, (3) 0021-8782 416-416.

Dowker SEP, Elliott JC, Davis GR et al. (2006). Three-dimensional study of human dental fissure enamel by synchrotron X-ray microtomography EUROPEAN JOURNAL OF ORAL SCIENCES 114, () 0909-8836 353-359.
10.1111/j.1600-0722.2006.00315.x

Potter K, Sweet DE, Anderson P et al. (2006). Non-destructive studies of tissue-engineered phalanges by magnetic resonance microscopy and X-ray microtomography BONE 38, (3) 8756-3282 350-358.
10.1016/j.bone.2005.08.025

Davis GR, Elliott JC (2006). Scintillator to CCD coupling in X-ray microtomography - art. no. 631817 Developments in X-Ray Tomography V 6318, () 0277-786X 31817-31817.
10.1117/12.679407

Cherukara GP, Davis GR, Seymour KG et al. (2005). Dentin exposure in tooth preparations for porcelain veneers: a pilot study. J Prosthet Dent 94, (5) 0022-3913 414-420.
10.1016/j.prosdent.2005.08.016

Elliott JC, Bollet-Quivogne FRG, Anderson P et al. (2005). Acidic demineralization of apatites studied by scanning X-ray microradiography and microtomography MINERALOGICAL MAGAZINE 69, (5) 0026-461X 643-652.
10.1180/0026461056950276

DAVIS GR (2005). Explicit control of image noise and error properties in cone-beam microtomography using dual concentric circular source loci Nuclear Instruments and Methods in Physics Research A 547, () 0168-9002 679-685.
10.1016/j.nima.2005.03.137

Balch DK, O'Dwyer JG, Davis GR et al. (2005). Plasticity and damage in aluminum syntactic foams deformed under dynamic and quasi-static conditions MAT SCI ENG A-STRUCT 391, (1-2) 0921-5093 408-417.
10.1016/j.msea.2004.09.012

Wong FS, Anderson P, Fan H et al. (2004). X-ray microtomographic study of mineral concentration distribution in deciduous enamel. Arch Oral Biol 49, (11) 0003-9969 937-944.
10.1016/j.archoralbio.2004.05.011

Fearne J, Anderson P, Davis GR (2004). 3D X-ray microscopic study of the extent of variations in enamel density in first permanent molars with idiopathic enamel hypomineralisation. Br Dent J 196, (10) 0007-0610 634-638.
10.1038/sj.bdj.4811282

Davis GR, Elliott JC (2004). Aspects of X-ray microtomography equipment design DEVELOPMENTS IN X-RAY TOMOGRAPHY IV 5535, () 0277-786X 182-190.
10.1117/12.556311

Dowker SEP, Elliott JC, Davis GR et al. (2004). Synchrotron x-ray microtomographic investigation of mineral concentrations at micrometre scale in sound and carious enamel CARIES RES 38, (6) 0008-6568 514-522.
10.1159/000080580

Davis GR, Dowker SEP, Elliott JC et al. (2003). Synchrotron x-ray microtomography of brown spot and stained fissure enamel. JOURNAL OF DENTAL RESEARCH 82, () 0022-0345 507-507.

Wassif HS, Davis GR, Dowker SEP et al. (2003). X-ray microtomography measurement of enamel mineral concentrations. JOURNAL OF DENTAL RESEARCH 82, () 0022-0345 516-516.

Dowker SE, Elliott JC, Davis GR et al. (2003). Longitudinal study of the three-dimensional development of subsurface enamel lesions during in vitro demineralisation. Caries Res 37, (4) 0008-6568 237-245.
10.1159/000070865

Justice I, Derby B, Davis G et al. (2003). Characterisation of void and reinforcement distributions in a metal matrix composite by X-ray edge-contrast microtomography SCRIPTA MATER 48, (9) 1359-6462 1259-1264.
10.1016/S1359-6462(03)00050-2

Davis GR, Elliott JC (2003). High definition X-ray microtomography using a conventional impact X-ray source JOURNAL DE PHYSIQUE IV 104, () 1155-4339 131-134.
10.1051/jp4:200300045

Mercer CE, Anderson P, Davis GR (2003). Sequential 3D X-ray microtomographic measurement of enamel and dentine ablation by an Er:YAG laser. Br Dent J 194, (2) 0007-0610 99-104.
10.1038/sj.bdj.4809883

Mercer CE, Anderson P, Davis G (2003). Sequential measurement of enamel and dentine ablation by an Er : YAG laser using 3D X-ray microtomography LASERS IN DENTISTRY, PROCEEDINGS 1248, () 0531-5131 131-134.
10.1016/S0531-5131(02)01322-5

Davis GR, ELLIOTT JC, Stock SR et al. (2003). Three-dimentional mapping of fatigue crack position via a novel X-ray phase contrast approach Advances in X-ray Analysis 46, () 314-319.

Müller F, Heath MR, Ferman AM et al. (2002). Modulation of mastication during experimental loosening of complete dentures. Int J Prosthodont 15, (6) 0893-2174 553-558.

Davis GR (2002). Modelling tomographic cone-beam projection data from a polyhedral phantom MEAS SCI TECHNOL 13, (8) 0957-0233 1336-1340.
10.1088/0957-0233/13/8/323

DAVIS GR, Elliott JC, Lee W-K et al. (2002). Fatigue cracks in aluminum samples studies with X-ray phase contrast imaging and with absorption microtomography. Advances in X-ray Analysis 45, () 123-126.

ANDERSON P, Dowker SEP, Davis GR et al. (2002). Non-destructive 3D structural studies by X-ray microtomography. Advances in X-ray Analysis 45, () 485-490.

DAVIS GR, Elliott JC (2002). X-ray microtomography scanner for low noise imaging using a laboratory source. GIT Imaging and Microscopy 4, () 44-45.

Contact

Dr Graham Davis

This email address is being protected from spambots. You need JavaScript enabled to view it.
+44 20 7882 5967 (Phone)
+44 20 7882 7931 (Fax)

Dental Physical Sciences Unit
2nd Fl. Francis Bancroft Building
Queen Mary, University of London
Mile End Road
London
E1 4NS

 

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