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Role of Anginosus group streptococci (AGS) in chronic lung infections

Associated Centre/s:  Clinical and Diagnostic Oral Sciences

Associated Research:  Infection, Immunity and Inflammation

The commensal bacterial flora are increasingly recognised as having a role in pathogenic processes by affecting gene expression and behaviour in pathogenic species. One area of interest is the interactions occurring within the mixed microbial populations that are present in chronic lung infections including cystic fibrosis (CF). AGS have been highlighted as having a potentially key role in triggering the onset of periodic exacerbations occurring in patients with CF and other chronic lung infections.

A selective agar medium has been developed and used to isolate AGS from sputa from a range of chronic lung infections. Biofilm models of AGS and Pseudomonas aeruginosagrowing together are being used to study the effects of co-culture on both partners with respect to gene expression and bacterial proliferation.

Key Publications

R.D. Waite, Wareham, D.W., Gardiner, S. and Whiley, R.A. (2012).  A simple, semi-selective medium for the anaerobic isolation of Anginosus group streptococci from patients with chronic lung disease. Journal of Clinical Microbiology 50(4):1430-2.

Contact

Dr Robert Whiley
Senior Lecturer

r.a.whiley@qmul.ac.uk
+44 20 7882 2389

Research Centre for Clinical & Diagnostic Oral Sciences
Blizard Building
Barts & The London
Queen Mary's School of Medicine & Dentistry
4 Newark Street
London E1 2AT
UK

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