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Mapping the Spatial and Temporal Progression of Enamel Biomineralisation using Synchrotron X-ray Diffraction

Associated Centre/s: Oral Growth and Development
Associated Research: Caries, Hard Tissues and Materials Research

Research Programme Funder: Wellcome Trust

Human dental enamel formation begins in utero and for most teeth takes several years to complete. It is a complex biological, physicochemical process where mineralisation progresses heterogeneously in space and time. It results in an enamel tissue which is highly mineralized, and contains a hierarchical, anisotropic distribution of apatite crystallites. Lost enamel tissue cannot regenerate, therefore it is important to understand its mineralisation in an effort to design improved in vivo mineral growth processes for regenerative dentistry and allow the possibility to grow a synthetic whole or partial tooth. Human dental enamel samples across a range of developmental stages available through archaeological collections are used to explore the spatial and temporal progression of enamel biomineralisation in order to advance clinical regenerative dentistry.

PI:  Maisoon Al-Jawad
CoI:  Janet Montgomery (Durham University)
PDRA: Lisa Simmons

Research Programme Status: Active

Contact

Dr Maisoon Al-Jawad

m.al-jawad@qmul.ac.uk
+44 20 7882 5960 (Phone)
+44 20 7882 7979 (Fax)

Dental Physical Sciences Unit
2nd Fl. Francis Bancroft Building
Queen Mary, University of London
Mile End Road
London
E1 4NS

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